Objective To discuss the clinical value of MRI contrast-enhancement scan in the evaluation of cerebral metastasis after radical mastectomy of breast cancer. Methods Clinical and MRI data of 32 patients with cerebral metastasis after radical mastectomy of breast cancer were retrospectively analyzed. All cases were Examinedwith conventional brain T1WI, T2WI plain scan, fluid attenuated inversion recovery (FLAIR) ,diffusion weighted imaging (DWI) scan and T1WI enhancement scan.To analyzed the display ability of all sequence in the metastatic lesions. Results 284 parenchyma lesions were distributed in the brain with all the scan sequence,whichmetastased in the brain parenchyma and meningeal . All the lesions showed heterogeneous hypointense or isointense on T1WI, hyperintense or isointense on T2WI, FLAIR and DWI with signal uniform or non-uniform, The solid masses were enhanced at different extension. The detection rate of the enhanced scanning to the metastasis was higher than other scanning sequences, The difference was statistically significant (P<0.05). Conclusion MRI multiple sequence scan were helpful for diagnosis and differential diagnosis of brain metastasis after radical mastectomy of breast cancer, Contrastenhanced scanning is the first choice because of whichcan significantly improve the detection rate of brain metastases.