Objective To investigate the clinic effect of rapid rehabilitation nursing in patients with laparoscopic gastrointestinal surgery. Methods 44 cases with laparoscopic gastrointestinal surgery in our hospital from December 2015 to August 2016 were selected and divided into common group and evidence-based group. Common group was given regular nursing and evidence-based group was given evidence-based nursing based on common group, and the clinical effect were observed and compared. Results The defecation time, off-bed activity time, evacuation time of evidencebased group were shorter than common group, adverse reaction rate of evidence-based group was lower than that of common group (0.9% vs 27.2%), patients’ satisfaction degree was higher than that of common group (90.91% vs 72.73%), the differences were statistical significance (P<0.05).Conclusion Rapid rehabilitation nursing on laparoscopic gastrointestinal surgery can lower adverse reaction rate and help patients with quick recovery. It is an effective intervention method and is worthy of clinic application.