目的 分析淋巴细胞主动免疫治疗对封闭抗体阴性复发性流产患者妊娠结局的影响。方法 选取2015年7月-2016年3 月我院70例确诊并给予治疗的封闭抗体阴性复发性流产患者，将所有患者随机分为两组，各35例。对照组采用免 疫球蛋白被动免疫治疗与常规治疗相结合，观察组采用淋巴细胞主动免疫治疗，比较两组间经过治疗后封闭抗体 阳性情况、治疗后成功妊娠率及封闭抗体阳性与阴性妊娠成功率。结果 观察组患者治疗后封闭抗体阳性率明显高 于对照组，差异显著(P＜0.05)；观察组患者治疗后妊娠成功率为82.86%，明显高于对照组60.00%，差异显著(P ＜0.05)。结论 采用淋巴细胞主动免疫治疗封闭抗体阴性复发性流产效果明显，增加了母体中封闭抗体阳性率，提 高了妊娠成功率，在临床应用中值得推广。

Objective To analyze the effect of lymphocyte active immunotherapy on pregnancy outcome of patients with recurrent and negative abortion of closed antibody. Methods A total of 70 patients with recurrent spontaneous abortion with closed antibody diagnosed and treated in our hospital from July 2015 to March 2016 were randomly divided into two groups of 35 patients. Control group using immunoglobulin passive immunization therapy combined with conventional treatment, observation group with lymphocytes active immunotherapy, comparison between the two groups after treatment of closed antibody positive situation, the successful pregnancy rates after treatment and closed antibody positive and negative pregnancy success rate. Results The positive rate of closed antibody was significantly higher in the observation group than in the control group (P<0.05). After treatment, the pregnancy success rate of the observation group was 82.86%, which was significantly higher than that of the control group (P<0.05). Conclusion Active immunotherapy using lymphocytes closed antibody negative effect of recurrent miscarriage, increased the rate of positive of antibody of matrix closed, improves the success rate of pregnancy, is worth popularization in clinical application.