目的 胃癌是世界上最常见的恶性肿瘤之一,内镜是诊断胃癌的主要手段,但仍有缺陷, 有必要寻找一条安全和准确 的检查方法。方法 选取2015年5月至2017年6月在我院行内镜检查胃癌和正常对照组各20例, 采用双光子荧光显微 技术对胃癌患者和对照组进行研究，以明确这种无创技术对胃癌疾病诊断的意义。结果 胃癌组和对照组双光子荧 光显微成像无论在腺体结构和细胞形态上均有显著差异。结论 双光子荧光显微成像技术在一定程度上有助于胃癌 的诊断。

Objecitve Gastric cancer (GC) is one of the most common malignant tumors in the world. Endoscopy is the main method for the diagnosis of gastric cancer. But it also has some defects. It is necessary to find a more safer and more accurate examination method. Methods 20 GC patients and 20 healthy volunteers were involved. These people underwent gastroscopy in our hospital during May 2015 to June 2017. Two-photon excitation fluorescence imaging was used to observe value of this technique in diagnosis of gastric cancer. Results There were significant differences between the two groups in both the structure and cellular morphology of the gastric cancer group and the control group. Conclusion Two-photon excitation fluorescence imaging is helpful for the diagnosis of gastric cancer