目的 探讨和分析胎膜早破的相关性危险因素，并且对胎膜早破的妊娠结局的影响进行研究，以期为临床早期诊断 未足月胎膜早破，并采取相关的有效手段进行干预提供客观的理论依据。方法 入选2014年1月-2016年1月于我院分 娩的胎膜早破的孕产妇100例，入选孕产妇均妊娠满28周，但不满37周，根据孕周不同分为观察A、B、C三组，分析 未足月胎膜早破的相关性因素，以破膜时间不同对妊娠结局的影响。结果 未足月胎膜早破主要相关因素为生殖道 感染（阴道炎、盆腔炎）、人工流产史和胎位异常（臀位、头盆不称），分别占30%、22%和14%；三组之间剖宫产 率和自然分娩率差异具有显著性，P＜0.05，提示胎膜早破孕周越大，自然分娩率越高，而剖宫产率则恰恰相反， 随孕周增大剖宫产率逐渐下降；不同破膜时间的羊膜腔感染、产褥病率有显著的差异，P＜0.05，提示破膜时间超 过24小时羊膜腔感染和产褥病发生率明显升高。结论 胎膜早破的主要相关因素有生殖道感染、人流史等，应当加 强育龄妇女孕前检查，重视孕期保健，在临床处理当中应当根据患者个性化特征选择分娩方式终止妊娠；孕周越 小，胎膜破裂时间越长，结局越差，应给与及时的干预，才能够从根本上改善这一情况。

Objective To analyze the related risk factors of premature rupture of membrane and its impact in the pregnancy outcome and provide the objective theory basis in the early diagnosis of preterm premature rupture of membrane and take the effective intervention measures. Methods 100 pregnant women of premature rupture of membrane delivered from January 2014 to January 2016 in our hospital were selected. The gestational weeks were 28w-37w. The subjects were divided into Group A, Group B and Group C according to the different gestational weeks. The correlation factors of preterm premature rupture of membrane and the impact of rupture time in the pregnancy outcome was analyzed. Results According to the related factors for preterm premature rupture of membrane, the rate of the reproductive tract infection (colpitis, pelvic inflammatory disease), history of induced abortion and abnormal fetal position (breech delivery, cephalopelvic disproportion) accounted for 30%, 22% and 14%. The rate of Cesarean section and natural delivery for three groups was significantly different (P<0.05), as the gestational weeks were extended, the rate of natural delivery was higher and the rate of Cesarean section was lower. For the different rupture time, the rate of intraamniotic infection and puerperal morbidity was signficantly different (P<0.05), as the rutpure time exceeded 24 hours, the rate of intraamniotic infection and puerperal morbidity was greatly increased. Conclusion The major factors of premature rupture of membrane include reproductive tract infection and history of induced abortion. It needs to focus on the pre-pregnancy checks and antenatal care and choose the suitable delivery mode according to the patient’s conditions. Based on the shorter gestational weeks, the pregnancy outcome is worsened with the longer rupture time. The proper intervention can improve the clinical symptom.