目的 探索丙基硫氧嘧啶与甲巯咪唑对比医治甲状腺功能亢进症的不良反应及临床效果。方法 选取2014年1月-2016 年2月在我院接受医治的108例甲状腺功能亢进患者为对象。108人随机分两组，A组（n=54），每日服用丙硫氧嘧啶 三次，每次100mg，B组（n=54）每天给药3次甲巯咪唑，每次10mg。连续医治3个月，观察疗效。结果 医治后患者 的病情均有明显好转，且两组对比没有明显差异（P>0.05）。A组患者出现白细胞数目减少和皮疹人数少于B组，肝 脏功能受损人数相同，两组在不良反应发生方面没有产生显著性差异（P>0.05）。结论 丙基硫氧嘧啶与甲巯咪唑 医治甲状腺功能亢进症疗效确切，治疗效果没有明显的统计学差异(P>0.05)。甲巯咪唑药物治疗时，发生白细胞数 目减少和皮疹方面的不良反应较丙基硫氧嘧啶更为明显。

Objective To explore the clinical effects and adverse reactions of comparison of propylthiouracil and methimazole in treatment of hyperthyroidism. Methods 108 patients with hyperthyroidism treated in our hospital from January 2014 to February 2016 were selected as the subjects and were randomly divided into group A (n=54) and group B (n=54). The patients in group A took propylthiouracil three times per day and100mg once while patients in group B (n=54) took methimazole times daily a day and 10mg each time. After 3 months of continuous treatment, the curative effect was observed. Results After treatment, the patient's condition was obviously improved, and there was no significant difference between the two groups (P>0.05). In group A, The number of patients with leukocytes decreased and rashes in group A was less than that in group B, and the number of patients with damaged liver function in two groups was the same. There was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion The treatment of propylthiouracil and methimazole in treatment of hyperthyroidism has curative effect, and there is no significant difference in the effect of treatment (P>0.05). When patients are treated with methimazole, the adverse reaction of the number of leukocyte reduction the rash is more obvious than the treatment of propylthiouracil.