目的 分析胃镜下活检在胃黏膜高级别上皮内瘤变诊断中的意义。方法 我院2015年8月-2017年2月所收治疑似高级 别上皮内瘤变患者50例，对比术前活检及术后病理检查结果。结果 术后病理组织诊断下胃镜活检诊断结果符合率 为76.00％（38/50）。两种诊断方法下结果对比存在显著差异（P＜0.05）。结论 胃镜下活检对胃黏膜高级别上皮 内瘤变患者的临床诊断效果钳夹，需多点取材并结合术后病理组织学诊断以提高准确率。

Objective To analyze the significance of endoscopic biopsy in the diagnosis of high-grade intraepithelial neoplasia of gastric mucosa. Methods 50 patients with suspected high-grade intraepithelial neoplasia were treated in our hospital from August 2015 to February 2017. The results of preoperative biopsy and postoperative pathological examination were compared. Results The coincidence rate of the diagnosis of gastroscope biopsy under pathological diagnosis was 76% (38/50). There were significant differences in the results of the two diagnostic methods (P<0.05). Conclusion The clinical effect of endoscopic biopsy in patients with high-grade intraepithelial neoplasia of gastric mucosa needs to be collected more points and combined with postoperative histopathological diagnosis to improve the accuracy rate.