目的 探究应用他克莫司治疗患激素抵抗型肾病综合征的老年患者的临床疗效。方法 经数字表法随机性选取2015年 10月-2016年10月期间内来我院就诊的患激素抵抗型肾病综合征的老年患者60例，根据不同用药治疗方式均分成对 照组和观察组，对照组患者应用环磷酰胺给予治疗，观察组患者应用他克莫司进行治疗。分析比较两组患者经不 同治疗方法治疗后的临床疗效情况。结果 两组患者经不同方法治疗后，试验组患者的总有效率(96.67%)显著高于 对照组患者的总有效率(60.00%)；对照组患者的总胆固醇值(5.98±1.92)mmol/L以及24小时尿蛋白(2.97±0.32) g/24h显著高于观察组患者的总胆固醇值（4.27±2.01）mmol/L以及24小时尿蛋白(0.81±0.24)g/24h；对照组患者 的白蛋白值(36.17±1.13)mmol/L显著低于观察组患者的白蛋白值(46.99±1.04)mmol/L，差异在统计学上均有意义 (P<0.05)。结论 对患激素抵抗型肾病综合征的老年患者应用他克莫司治疗后，可更安全有效的提高肾功能，值得 在临床广泛推广应用。

Objective To investigate the clinic effect of tacrolimus in treating steriod-resistant NS. Methods 60 cases with steriodresistant NS in our hospital from October 2015 to October 2016 were selected and divided into control group and observation group, control group was given cyclophosphamide and observation group was given tacrolimus. Compare the clinic effect of the two groups. Results After different treatment methods, total efficiency of observation group (96.67%) was higher than control group (60.00%). TC and 24h PRO of control group [(5.98±1.92)mmol/L, (2.97±0.32) g/24h]were higher than observation group [(4.27±2.01)mmol/L, (0.81±0.24)g/24h]. Albumin values of control group [(36.17±1.13)mmol/L] was lower than observation group [(46.99±1.04)mmol/L], the difference was statistically significanct (P<0.05). Conclusion The application of tacrolimus in treating steriod-resistant NS can improve renal function and is worthy of wide application.