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·腹部疾病·

持续蓝光照射和间隙蓝光照射治疗新生儿黄疸的临床疗效对比研究

作者:姜 凯 王广州

所属单位:河南省郑州市妇幼保健院新生儿科 (河南 郑州 450000)

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摘要

目的 探究持续性蓝光照射和间隙性蓝光照射治疗新生儿黄疸的临床疗效。方法 选取我院2013年6月-2015年2月期 间收治的64例黄疸新生儿,采用抽签方式分为:A组32人和B组32人,两组黄疸患儿先同时进行常规治疗,A组患儿 采用间隙性蓝光照射治疗,B组患儿采取持续性蓝光照射治疗。对两组患儿的各项体征和精神状态进行观察,记录 患儿的黄疸好转情况和不良反应进行。结果 A组(间隙组)和B组(持续组)的总有效率的差异没有统计学意义(93.75% vs 96.87%,P>0.05),A组(间隙组)患儿比B组(持续组)患儿的不良反应的发生率要低(34.38% vs 46.88%, P<0.05),差异具有统计学意义。结论 采用间隙性蓝光治疗与持续性的蓝光照射治疗两种方案对新生儿的黄疸都具 有明显的效果,而采用间隙性的蓝光照射治疗可以大程度的降低患儿的不良反应的发生率。

Objective To study the clinical effects of continuous and intermittent blue light irradiation in the treatment of neonatal jaundice. Methods From Jun. 2013 to Feb. 2015, a total of 64 neonates with jaundice in our hospital were taken as the clinical research objects, and they were randomly divided into A group (32 cases) and B group (32 cases). All the patients accepted conventional treatment, besides, patients in the A group were given intermittent blue light irradiation, and the other patients in the B group received continuous blue light irradiation. The physical signs and mental status of the two groups were observed, and the improved symptoms of jaundice and adverse reactions were recorded. Results There was no significant difference in total effective rate between A group (intermittent group) and B group (continuous group) (93.75% vs 96.87%,P>0.05), the incidence of adverse reactions in A group (intermittent group) was lower than that in B group(continuous group), and their difference was statistically significant (34.38% vs 46.88%, P<0.05). Conclusion Both continuous and intermittent blue light irradiation have significant effects on neonatal jaundice, meanwhile, the intermittent blue light irradiation can greatly reduce the incidence of adverse reactions.

【关键词】新生儿黄疸;蓝光照射;持续性;间隙性;常规治疗

【中图分类号】R722.17

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2017.02.019

前言

黄疸(jaundice)是常见的症候,是因胆红素的 代谢故障引发血清内的胆红素浓度增高而导致,患 者临床症状常为巩膜、粘膜、皮肤和其他组织被染 黄[1-2]。在新生儿中也较常见,较为严重时能够引起 新生儿智力发育和四肢协调能力,甚至可能导致死 亡,医学上称为胆红素脑病[3]。此类疾病严重的威胁 了新生儿的健康,也给患儿家庭带来了经济负担和精 神压力。临床上对新生儿黄疸常给予药物治疗,但效 果并不显著,对此一类有效的治疗方案是儿科当今的首要问题,在很多文献中提到,蓝光治疗在新生儿 的治疗效果显著,本次研究中针要选取我院2013年6 月~2015年2月期间收治的64例黄疸新生儿,分A组患 儿采用间歇性蓝光照射治疗,B组患儿采取持续性蓝 光照射治疗,在进行观察研究分析,详细经过下文所 示。