目的 通过比较干眼患者上下泪点栓塞术前、术后1月、3月后的泪膜破裂时间及Schirmer I 实验，分析上下泪点 栓塞对干眼患者泪液质量的影响。方法 前瞻性队列研究，选取在北京大学深圳医院就诊的干眼患者31例（42只 眼），测量术前、术后1月、3月后的泪膜破裂时间及Schirmer I实验，将所得数据进行单因素方差分析。结果 术 前、术后1月、术后3月BUT平均值分别为（4.12±1.57）秒、（8.33±1.62）秒、（7.67±1.60）秒，三组数据组 间差异有统计学意义（P<0.005）,进一步两两比较显示，术前组的BUT值显著小于术后1月组（P<0.005），术前组 的BUT值显著小于术后3月组（P<0.005），术后3月组的BUT值显著小于术后1月组（P<0.005）；术前、术后1月、术 后3月Schirmer I 实验平均值分别为（3.47±0.48）mm、（7.88±2.49）mm、（6.99±2.00）mm，三组数据组间差 异有统计学意义（P<0.005），进一步两两比较显示，术前组的BUT值显著小于术后1月组（P<0.005），术前组的 BUT值显著小于术后3月组（P<0.005），术后3月组的BUT值显著小于术后1月组（P<0.005）。结论 上下泪小点栓塞 可明显增加干眼患者的Schirmer I实验，泪膜稳定性明显改善，但随时间延长有所下降。

Obiective By comparing the break-up time and Schirmer I test of dry eye patients before and after 1 and 3 month of lacrimal punctum embolization.,Analyze the influence of lacrimal punctum embolization on the patients with dry eye tear quality. Methods In this prospective cohert study , 31 dry eye patients (42 eyes) from Peking University ShenZhen Hospital. Break-up time and Schirmer I test were tested at before and after 1 and 3 month of lacrimal punctum embolization. A one-way ANOVA was used for data analysis. Results The mean BUT of dry eye patient before and after 1 and 3 month of lacrimal punctum embolization, (4.12±1.57)S, (8.33±1.62)S, (7.67±1.60)S,respectively. The difference between the three datas was statistically significant (P<0.005). Further comparison each others shows , BUT value of preoperative group significantly less than group 1 month after surgery (P<0.005), BUT value of preoperative group significantly less than group 3 month after surgery (P<0.005), BUT value of group 1 month after surgery significantly less than group 3 month after surgery (P<0.005). The mean Schirmer I test of dry eye patient before and after 1 and 3 month of lacrimal punctum embolization, (3.47±0.48)mm, (7.88±2.49)mm, (6.99±2.00) mm,respectively. The difference between the three datas was statistically significant (P<0.005). Further comparison each others shows , Schirmer I value of preoperative group significantly less than group 1 month after surgery (P<0.005), Schirmer I value of preoperative group significantly less than group 3 month after surgery (P<0.005), Schirmer I value of group 1 month after surgery significantly less than group 3 month after surgery (P<0.005). Conclusion Influence of lacrimal punctum embolization can obviously increase the Schirmer I test in patients with dry eye, appears stability obviously improved,But with the extension of time.