目的 分析合并冠心病对重度、极重度COPD患者的急性加重住院次数、住院时间、死亡率等的影响。方法 回顾性分 析急性加重住院的重度及极重度COPD患者227例,依据有无冠心病合并症将这批患者分为合并冠心病组（69例）及不 合并冠心病组（158例）；对其住院时间、急性加重频度、死亡率等参数进行分析比较。结果 两组COPD患者共死亡 32例，合并冠心病组死亡15例, 非合并冠心病组死亡17例；两组患者死亡率差异有统计学意义。无合并症组最后 一次住院时长为（10.9±7.1）天；从最后一次住院往前计算两年内急性加重住院次数为（3.9±5.7）次；有合并 症组最后一次住院时长为（16.1±11.5）天；从最后一次住院往前计算两年内急性加重住院次数为（6.5±5.23） 次；此两项指标两组之间差别均具有统计学意义（P均<0.05）。结论 合并冠心病增加了COPD患者的住院时间、急 性加重住院频次及死亡率。

Objective To analyze the impact of coronary heart disease to severe and very severe COPD patients in acute exacerbation hospitalization, length of stay, mortality. Methods 227 COPD patients stage Ⅲ-Ⅳ clinical data was retrospective analyzed. They were divided into the coronary heart disease group (69 cases) and the control group (158 cases). Hospitalization length, frequency of exacerbations and mortality rates were analyzed and compared. Results There were 32 cases dead in two groups, 15 cases in the coronary heart disease group and 17 cases in the control group with statistically significant. The last hospitalization length was 16.1±11.5 days in the coronary heart disease group and (10.9± 7.1) days in the control group. The acute exacerbation hospitalization frequency is (6.5±5.23) in the coronary heart disease group and (3.9±5.7) in the control group in the last two years. The difference was statistically significant. Conclusion Coronary heart disease increases the duration of hospitalization, the frequency of exacerbations and mortality in patients with COPD patients.