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·胸部疾病·

布地奈德溶液吸入治疗小儿支气管哮喘的临床疗效研究

作者:凌 曦

所属单位:广东省韶关市妇幼保健院儿科 (广东 韶关 512023)

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摘要

目的 分析糖皮质激素吸入疗法在小儿支气管哮喘临床治疗过程中的应用效果。方法 择取本院2014年9月-2016年5 月期间收治的支气管哮喘患儿100例,按照患儿的入院时间以及患儿家长意愿,划分为观察组与对照组,每组各50 例。对照组患儿接受万托林+异丙托溴铵+生理盐水雾化治疗,观察组患儿接受常规治疗+布地奈德溶液吸入治疗, 对比两组患儿的临床治疗效果。结果 两组患儿治疗前的肺功能指标无明显差异,即相应数据对比,P>0.05,不 存在统计学意义;但两组患儿治疗后,观察组患儿的肺功能指标明显优于对照组患儿,相应数据组间进行对比, P<0.05,差异存在统计学意义;观察组患儿的临床治疗有效率为92.00%,对照组患儿的临床治疗有效率为74.00%, 两组数据进行对比,组间差异P<0.05,差异具有统计学意义。结论 小儿支气管哮喘临床治疗过程中,对患儿行布 地奈德溶液吸入疗法,可以有效改善患儿肺功能,提高患儿的临床治疗效果,促进早期康复,有利于患儿正常生长 发育,具有临床使用及推广价值。

Objective To analyze the application of glucocorticoid inhalation therapy in children with bronchial asthma clinical effect of the treatment process. Methods 100 cases of bronchial asthma were selected in our hospital between September 2014 -2016 period in May, according to the time of admission of children and parents will, divided into observation group and control group, each group of 50 cases. The control group was treated with salbutamol and ipratropium bromide saline atomization treatment, observation group received routine treatment and budesonide inhalation treatment, clinical curative effect of the two groups were compared. Results The two groups of children lung function before treatment was no significant difference, that the corresponding data comparison, P> 0.05, there is no statistically significant; but the two groups of children treatment, lung function in children was significantly better than the observation group children in the control group, the corresponding data between groups were compared, P <0.05, statistically significant differences; children with clinical observation group was 92.00%, the clinical treatment of children with the control group was 74.00%, two sets of data were compared, differences between the groups P <0.05, significant difference has obvious nature. Conclusion Children with bronchial asthma clinical treatment, treated with budesonide inhalation therapy can effectively improve lung function in patients, improve the patient's clinical curative effect, promote early rehabilitation, is conducive to the normal growth and development of children, and is worthy of clinical application and popularization value.

【关键词】布地奈德溶液吸入;小儿支气管哮喘;治疗效果

【中图分类号】R974+.3; R725.6

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2016.06.007

前言

支气管哮喘为儿科常见性呼吸道疾病,病情诱发 因素具有较强的复杂性,与多种炎性介质、炎性细胞 存在密切关联。临床表现主要特征为双肺存在广泛哮 鸣音、呼吸困难以及咳嗽等,且具有反复发作、病情 迁延等特征,患儿如果没有及时接受有效治疗,极大 影响其生活质量,甚至威胁其生命安全。布地奈德溶 液吸入疗法是现阶段临床医学治疗小儿支气管哮喘的主要措施,药物可以直接在患儿病灶区域发挥作用, 而且浓度相对较高,操作安全[1]。本院为了进一步探 索布地奈德溶液吸入疗法在小儿支气管哮喘临床治疗 中的应用效果,明确小儿支气管哮喘临床治疗最佳途 径,遂进行了如下实验。