目的 系统评价氟比洛芬酯注射液术前使用减轻手术患者术后疼痛的效果。方法 电子检索CNKI、PubMed、万方数据 库等2000年至2016年9月关于氟比洛芬酯注射液术前使用减轻术后疼痛作用的文献，按系统评价方法筛选文献、评 价研究质量并提取资料后采用RevMan 5.3软件对文献术后6h、12h、24h的视觉模拟评分(VAS)进行Meta分析。结果 最终纳入随机对照试验(RCT)16篇，共计804例患者。Meta分析各时间点VAS评分结果显示:①术后6h VAS评分[SMD:- 0.50,95%CI(-0.84,-0.17),P=0.003]；②术后12h VAS评分[SMD:-0.70,95%CI(-1.16,-0.25),P=0.002]；③术后24h VAS评分[SMD:-0.15,95%CI(-0.27,-0.04),P=0.008]。与术后给药的常规镇痛组相比，术前给药的超前镇痛的VAS 在3个时间点均降低，差异有统计学意义。结论 氟比洛芬酯注射液用于超前镇痛可以提供有效的术后镇痛。

Objective To evaluate the effectiveness of preoperative administration with Flurbiprofen Axetil for postoperative pain relief. Methods Databases such as PubMed, WANFANG,CNKI were searched to identify randomized controlled trials (RCTs) involved in Flurbiprofen Axetil for preemptive analgesia from 2000 to 2016. The quality of studies were selected and evaluated, and Visual analogue score (VAS) at 6h, 12h, 24h after surgery were calculated by Review manager 5.3 software. Results A total of 16 RCT studies involving 804 patients were included in this study. The results of this Meta-analysis showed that: 6h-VAS[SMD:-0.50,95%CI(-0.84,-0.17),P=0.003],12h-VAS[SMD:-0.70,95%CI(- 1.16,-0.25),P=0.002], 24h-VAS[SMD:-0.15,95%CI(-0.27,-0.04),P=0.008]. Conclusion The present data shows that preoprative Flurbiprofen axetil administration is efficacy for reducing acute postoperative pain.