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CT增强扫描在评估原发性肝癌介入治疗近期疗效中的应用价值分析*

作者:朱芳成 陈鸿光 郎 清

所属单位:四川省达州市中心医院感染科(四川 达州 635000)

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摘要

目的 探讨CT增强扫描在评估原 发性肝癌介入治疗近期疗效中的应用价 值。方法 选取我院2015年4月-2017年1 月的收治的经导管肝动脉化疗栓塞术介 入治疗的38例原发性肝癌患者,患者术 后均进行了CT平扫及增强检查,以数字 减影血管造影(DSA)检查结果为“金标 准”,分析CT增强扫描在评估原发性肝 癌介入治疗近期疗效中的应用价值。结 果 DSA共检出59个病灶,CT平扫共检出 病灶41个(69.49%),CT增强共检出病灶 58个(98.30%),CT增强病灶检出率明显 高于CT平扫(P<0.05),但与DSA检查结 果相比无统计学意义(P>0.05)。CT增强 对≥3cm、<3cm大小的病灶诊断灵敏度 分别为94.44%、97.56%,明显高于CT平 扫(P<0.05);CT增强对病灶供血动脉来 源诊断灵敏度、特异度均明显高于CT平 扫(P<0.05);CT增强对合并门静脉癌栓 诊断灵敏度为70.83%,明显高于CT平扫 70.83%(P<0.05);CT检查显示碘油沉积类 型:完全型9个,缺损型22个,稀疏型11 个,新发病灶17个。结论 CT增强扫描能 有效评估原发性肝癌患者经导管肝动脉化 疗栓塞术介入治疗后的近期效果。

Objective To explore the application value of CT enhanced scanning in evaluating the short-term efficacy of interventional therapy for primary liver cancer. Methods 38 patients with primary liver cancer who received transcatheter hepatic artery chemoembolization for interventional therapy in our hospital from April 2015 to January 2017 were selected. All the patients underwent CT plain scan and enhanced examination after surgery. The results of digital subtraction angiography (DSA) were taken as the "gold standard" to analyze the application value of CT enhanced scanning in evaluating the short-term efficacy of interventional therapy for primary liver cancer. Results A total of 59 lesions were detected by DSA, 41 lesions were detected by CT non-enhanced scanning (69.49%), 58 lesions were detected by CT enhanced scanning (98.30%), and the detection rate of enhanced lesions was significantly higher than that of CT plain scanning (P<0.05), but there was no statistical significance (P>0.05). The diagnostic sensitivity of lesions greater than or equal to 3cm and less than 3cm was 94.44% and 97.56%, respectively, significantly higher than that of CT plain scan (P<0.05). The diagnostic sensitivity and specificity of enhanced CT were significantly higher than that of non-enhanced CT (P<0.05). The diagnostic sensitivity of enhanced CT for complicated portal cancer emboli was 70.83%, which was significantly higher than that of non-enhanced CT (P<0.05). CT examination showed that there were 9 total, 22 defect, 11 sparse and 17 new lesions. Conclusion CT enhanced scanning can effectively evaluate the short-term efficacy of interventional therapy after transcatheter hepatic artery chemoembolization in patients with primary liver cancer.

【关键词】CT增强扫描;原发性肝癌;介 入治疗;近期疗效;应用价值

【中图分类号】R735.7

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2019.02.009

前言

原发性肝癌是临床中常见的恶性肿瘤之一,诸多文献报道,肝脏 具有肝动脉和门静脉双重血液供应,故肝癌病情进展速度快,根治性 切除术是原发性肝癌的治疗手段之一,但因原发性肝细胞癌患者早期 临床症状不明显,易被患者忽略,至出现明显临床症状就诊时多为中 晚期,在患者接受临床治疗时已失去外科手术切除的机会[1-3]。原发性 肝癌患者正常肝脏组织主要以门静脉供血为主,癌组织则以肝动脉供 血为主,经导管肝动脉化疗栓塞术是临床中常见的治疗手段,像肝癌 组织的供血血管注入栓塞剂或者化疗药物灭活癌细胞或抑制癌细胞的 扩散。但原发性肝癌经导管肝动脉化疗栓塞术治疗本质为姑息性治疗 手段,需要多次、重复治疗以保证其效果[4-5]。影像学检查是评估经导 管肝动脉化疗栓塞术临床效果的主要方式,为进一步探讨CT增强扫描 在评估原发性肝癌介入治疗近期疗效中的应用价值,本研究收集了38 例原发性肝癌患者的临床及影像学资料进行相关分析,现报道内容如 下。