摘要
目的研究弥散加权成像(DWI) 与磁共振血管成像(MRA)联合检测在急性 脑梗死(ACI)患者血管病变评估及临床意 义。方法 选取94例ACI确诊患者,分别 进行DWI和MRA检查,分析检查结果。结 果 经确诊,94例患者中单病灶63例,多 发病灶31例,治疗前后,患者NIHSS评分 分别为[(12.86±2.97)分和(8.72±1.64) 分,P<0.05];其中DWI检测阳性92例 (97.87%);显示患者两侧脑组织ADC值差 异显著(P<0.05),不同发病时间段患者 患侧ADC值及rADC先明显降低(P<0.05), 24h后显著升高(P<0.05);MRA检查阳性89 例(94.68%);血管狭窄程度与rADC呈正 相关,与治疗前NIHSS评分呈正相关,与 NIHSS评分治疗前后差值呈正相关;rADC 与治疗前NIHSS评分呈正相关,与NIHSS评 分治疗前后差值呈正相关。结论 DWI能 清楚显示ACI患者早期病灶位置和缺血程 度,MRA则可准确定位导致梗死发生的责 任血管及其狭窄程度,二者联合应用有助 于ACI患者早期诊断和病情评估,为临床 治疗提供理论依据,从而使患者获得及时 有效干预,缓解病情,改善预后。
Objective To study the evaluation and clinical significance of diffusion weighted imaging (DWI) and magnetic resonance angiography (MRA) in vascular lesions of patients with acute cerebral infarction (ACI). Methods 94 cases of ACI diagnosed patients were selected and given DWI and MRA examinations. The examinations results were analyzed. Results There were 63 single lesions and 31 multiple lesions in 94 patients after diagnosis, and the NIHSS scores were (12.86±2.97) points and (8.72±1.64) points respectively before and after treatment (P<0.05). 92 cases (97.87%) were positive by DWI, and there were significant differences in ADC value of bilateral brain tissue (P<0.05), and the ADC value and rADC of the affected side were first decreased significantly (P<0.05) and then increased significantly after 24h (P<0.05). 89 cases (94.68%) were positive by MRA examination. The degree of vascular stenosis was positively correlated with rADC, and was positively correlated with the NIHSS score before treatment, and was positively correlated with the difference value of NIHSS score before and after treatment. The rADC was positively correlated with NIHSS score before treatment, and was positively correlated with he difference value of NIHSS score before and after treatment. Conclusion DWI can clearly show the location of early lesions and the degree of ischemia in ACI patients. MRA can accurately locate the responsible vessels and its stenosis degree that lead to infarction. The combination of the two can be helpful for the early diagnosis and assessment of ACI, and can provide a theoretical basis for clinical treatment, thereby helping patients receive timely interventions to ease the disease and improve prognosis.
【关键词】弥散加权成像;磁共振血管成像;急性脑梗死;血管病变;联合检测
【中图分类号】R743.1;R445.2
【文献标识码】A
【DOI】10.3969/j.issn.1672-5131.2018.11.001
前言
急性脑梗死(Acute cerebral infarct,ACI)是因血栓形成或栓 塞等导致大脑供血动脉官腔狭窄或闭塞,引起支配区域脑组织供血不 足而发生坏死的疾病[1]。该病起病较急,进展迅速,预后不良,时间 窗内溶栓治疗有利于及时恢复缺血部位灌注,减小梗死范围,是控制 患者病情,改善神经功能缺损症状的有效手段,因此早期诊断和治疗 具有重要临床意义[2]。大量研究和临床经验表明,MRI在ACI诊断中具 有独特优势,近年来发展成熟的弥散加权成像(diffusion weighted imaging,DWI)和磁共振血管成像(Magnetic Resonance Angiography, MRA)已在临床广泛应用,其中MRI对超急性期脑梗死极具诊断价值,可 清晰显示发病6h缺血病灶,为溶栓治疗提供直观影响资料[3];MRA利用 血液流动增强效应,分辨直径达1mm,能清晰显示颅内血管狭窄或病变 情况,为明确责任血管提供理论依据[4]。本文采用DWI与MRA联合检测评 估ACI患者血管病变情况及其临床意义,结果详述如下。
中国CT和MRI杂志
第16卷, 第 11 期
2018年11月
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