摘要
目的 应用3.0T磁共振动脉自旋 标记(ASL)技术对比正常儿童与行颈总动 脉外膜交感神经网剥脱术前后的脑瘫患 儿脑血流量(CBF)发生的变化情况差异。 方法 应用Achieva/Intera PHILIPS 3.0T 核磁共振仪对30例正常儿童与30例行颈总 动脉外膜交感神经网剥脱术前一周内、术 后14天的单侧痉挛型脑性瘫痪患儿进行 常规序列、DWI、ASL等序列扫描,应用 MriCloud后处理工作站获得被检者大脑双 侧额叶、颞叶、顶叶、中央前回、内囊区 域、基底节、丘脑、小脑区域的CBF值, 使用配对t检验对数据进行统计学分析。 结果 正常儿童与脑瘫患儿进行对比,脑 瘫患儿患侧大脑皮质区、中央前回、基 底节、内囊、小脑区运动相关区域CBF较 低,差异有统计学意义;行颈总动脉外膜 交感神经网剥脱术后脑瘫患儿患侧上述区 域脑血流量有改善。结论 通过磁共振ASL 技术发现颈总动脉外膜交感神经网剥脱术 是一种有效的治疗脑性瘫痪的手术方法, 可以有效提高患儿脑血流量,改善大脑缺 血缺氧状态,缓解患儿临床症状。
Objective Comparison of changes in cerebral blood flow (CBF) between normal children and cerebral palsy children by using arterial spin labeling (ASL), Depament of Radiology, The second Affiliated Hospital of Xinjiang medical University,before and after the cervical perivascular sympathectomy. Methods Using Achieva/Intera PHILIPS 3.0 T magnetic resonance imaging scan 30 normal children and 30 unilateral spastic cerebral palsy children who underwent cervical perivascular sympathectomy preoperative one week and postoperative 14 days in regular sequence, DWI, ASL and other sequences. The CBF value of different areas of the clients was obtained by MriCloud post-processing workstation, which include Bilateral of frontal lobe, the temporal lobe, the parietal lobe. Central front return,Inner sac region,The basal ganglia,The thalamus,The cerebellum were compared between two groups, A paired t-test was used for statistical analysis. Results In comparison to the control group. The CBF values in the patient group decreased. There were significant differences between two groups in Cerebral cortex, anterior central gyrus, basal ganglia, inner capsule, cerebellum in the affected side,children with cerebral palsy had improved Cerebral blood flow in above areas after the cervical perivascular sympathectomy. Conclusion ASL found that cervical perivascular sympathectomy is an effective treatment of cerebral palsy surgery,And can significantly improve the CBF of children with cerebral palsy,improving cerebral ischemia and hypoxia,relieve the clinical symptoms of children.
【关键词】磁共振成像;颈总动脉外膜交 感神经网剥脱术;动脉自旋标 记;脑瘫患儿
【中图分类号】R445.2;R748
【文献标识码】A
【DOI】10.3969/j.issn.1672- 5131.2017.12.001
前言
脑瘫是一种常见的残疾,它与儿童出生时发生的损伤或先天性畸 形有关[1]。颈总动脉外膜交感神经网剥脱术是手术治疗脑瘫的方法之 一,手术作用机理与改善脑血流相关[2]。因此评价与测量脑组织血流 灌注在确定手术疗效及判断预后中有重要价值,CBF是公认的反映血流 动力学变化的重要指标,测量CBF有多种方法,例如CT灌注成像、MRI 动态增强灌注成像[3-4],但这些方法都是有创的,对于脑瘫儿童急需一 种安全无创、可反复测量脑血流量的技术。动脉自旋标记(ASL)作一种 经典的无创的核磁共振脑功能检测技术,能够定量和定性地评价脑组 织血流动力学状态,不仅可用于大脑病变的诊断及预后评估,同时也 可作为手术治疗前后的客观评价手段[5]。
中国CT和MRI杂志
第15卷, 第 12 期
2017年12月
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