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双源CT在评估冠心 病患者存活心肌的 临床应用价值

作者:陆 昇1 周啸虎2

所属单位:1.东南大学附属中大医院放射科 (江苏 南京 210044) 2.江苏省南京市第一医院放射科 (江苏 南京 210000)

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摘要

目的 探讨双源CT在冠心病患者 存活心肌中的临床评估价值。方法 收 集我院2012年9月至2015年12月期间所 收治的经冠脉造影检查诊断为冠心病 患者42例进行回顾性分析,患者均行 双源CT检查及心肌双核素SPECT显像检 查。以双核素SPECT显像检查结果为基 准,计算双源CT诊断冠心病患者存活 心肌的敏感性、特异性及符合率。结 果 42例患者共714个心肌节段,以双核 素SPECT显像为基准,双源CT对存活心 肌的诊断敏感性为80.0%(120/150),特 异度为98.9%(549/555),诊断符合率为 93.7%(669/714),与双核素SPECT显像结 果相比无统计学意义(P﹤0.05)。结论 双 源CT图像的时间及空间分辨率较高,结合 首过灌注及延迟期强化情况可对心肌存活 情况进行可靠判定,诊断准确性与经济性 均较高,可作为评估冠心病心肌存活情况 的首选检查方法。

Objective To investigate the clinical value of dual-source CT in evaluating viable myocardium in patients with coronary heart disease. Methods A total of 42 patients with coronary heart disease diagnosed by coronary angiography in our hospital between September 2012 and December 2015 were retrospectively analyzed. All patients underwent dual-source CT and dual-isotopic myocardial SPECT imaging examination. Based on the results of dual-isotopic myocardial SPECT imaging examination, the sensitivity, specificity and accuracy of dual-source CT in the diagnosis of viable myocardium in patients with coronary heart disease were calculated. Results There were a total of 714 myocardial segments in 42 cases of patients. Based on the results of dualisotopic myocardial SPECT imaging examination, the sensitivity, specificity and accuracy of dual-source CT in the diagnosis of viable myocardium were 80.0% (120/150), 98.9% (549/555) and 93.7% (669/714) respectively. Compared with the SPECT imaging results, there were no significant differences (P<0.05). Conclusion The time and spatial resolutions of images of dual-source CT are high. Combined with first-pass perfusion and enhancement in delayed phase, the myocardial viability can be reliably determined. The diagnostic accuracy and the economy both are high, which can be used as the first choice to evaluate the myocardial viability in patients with coronary heart disease.

【关键词】冠心病;双源CT;双核素 SPECT显像;存活心肌; 延迟期灌注

【中图分类号】R541.4;R445.3

【文献标识码】A

【DOI】10.3969/j.issn.1672- 5131.2017.12.009

前言

冠心病为常见与多发心血管疾病,可引起心衰、心肌梗死甚至猝 死等不良后果。心肌缺血为冠心病病情进展的重要病理过程,随着临 床研究的深入,已经有动物试验显示[1],受到心肌缺血发生速度、持 续时间、再灌注与否等因素影响,心肌梗死后的局部室壁运动异常区 域除有坏死心肌外,也有部分存活心肌,其为心肌缺血后的特殊存 在形式。有专家提出[2],通过有效血运重建可使存活心肌的功能获得 部分或完全恢复,从而实现左室功能的逆转,改善患者预后。而对于 无存活心肌的冠心病患者,血运重建无法恢复局部心肌功能 ,而有 存活心肌的冠心病患者行血运重建后的病死率显著低于无存活心肌患 者[3]。由于坏死心肌往往与存活心肌同时存在,因而于术前对患者存 活心肌情况进行判断,对患者治疗方案的制定及预后的评估有重要意 义。本研究以我院2011年1月至2014年12月收治的42例冠心病患者为 例,对双源CT在冠心病患者存活心肌评估中的应用价值进行探讨,现 报道如下。