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论著-头颈部

子宫癌肉瘤的CT、MRI影像学分析

作者:孙 琳 尹韶晗 吕晓飞 谢传淼

所属单位:中山大学肿瘤防治中心医学影像中心(广东 广州 510060)

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摘要

目的 探讨分析子宫癌肉瘤的 CT、MRI表现特点,提高其影像学诊断 的正确率。方法 回顾性分析我院 2010 年1月至2016年8月经病理证实的17例子 宫癌肉瘤患者的CT、MRI表现。结果 根 据肿瘤形态分为两型,I型表现为宫腔 或宫颈管内不规则或类圆形巨大肿块(7 例);II型表现为息肉状或不规则较小肿 块,或单纯性子宫内膜增厚,与子宫内 膜癌酷似(10例)。其影像学特征:⑴平 扫呈等密度或等信号,偶见混杂信号, T2WI呈稍高或混杂信号,子宫肌层受侵 时T2WI上低信号结合带消失或中断。 ⑵增强扫描多低于子宫肌层强化程度。 ⑶DWI呈高信号,ADC平均值较高,测得 为(1.02±0.3)×10-3mm2 /s。⑷瘤内常 见流空血管影,多伴有囊变及坏死。结 论 子宫癌肉瘤的形态、瘤内流空血管影 及较高的ADC值,将有助于与子宫内膜癌 鉴别,MRI对瘤内囊变、坏死、出血的诊 断以及肿瘤浸润深度的评估有着重要意 义。

Objective To investigate and analysis the CT and MRI features of uterine carcinosarcoma and to promote diagnostic accuracy of the disease. Methods Clinical data, CT and MR imagings of 17 uterine carcinosarcoma patients confirmed by pathology were reviewed and analyzed retrospectively. Results All the cases presented with two patterns, type I showed large irregular or round-like mass occurred in uterine cavity or cervical canal (n=7), type II showed polypoid or irregular smaller lumps, or simple endometrial thickening, which were similar to endometrial carcinoma(n=10). The radiographic features are as follows: ⑴moderate density on plain CT scans, isointensity or sometimes mixed signal intensity on unenhanced T1-weighted imagings and intermediate or heterogeneous signal intensity on T2-weighted images; the disappearance or discontinuity of junctional low-intensity band on T2-weighted imagings indicating myometrium invasion, ⑵common hypointense or low-density relative to adjacent myometrium on contrastenhancement imagings, ⑶heterogeneous hyperintensity on diffusion-weighted imagings with higher mean ADC value of (1.02±0.3)×10-3mm2 /s, ⑷intratumoral flow voids and cystic necrosis likely to be found. Conclusion Characteristics of uterine carcinosarcoma including patterns of the tumor, intratumoral flow voids and higher ADC values will do help in differential diagnosis with endometrial carcinoma. MRI is of great significance in diagnosis of intratumoral hemorrhage and cystic necrosis, as well as assessment of the depth of tumor invasion.

【关键词】子宫;癌肉瘤;计算机体层 成像;磁共振成像

【中图分类号】R445.2;R737.3

【文献标识码】A

【DOI】10.3969/j.issn.1672- 5131.2017.12.027

前言

子宫癌肉瘤是一种罕见的高度恶性子宫肿瘤,占所有子宫肿瘤不 到5%的比例,过去一直被认为是子宫肉瘤最常见的亚型,因研究发现 子宫癌肉瘤的生物学行为与高级别子宫内膜癌相似,目前已将子宫癌 肉瘤归为子宫内膜癌的一个特殊亚型[1-3]。但与子宫内膜癌不同的是, 子宫癌肉瘤恶性程度高,预后差,5年生存率不到40%,治疗方式上两 者也有所不同[1,4],因此将两者正确区分开来是至关重要的。本研究旨 在回顾性分析我院17例子宫癌肉瘤病例在CT及MRI上的表现,为诊断及 鉴别提供依据。