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高速多排螺旋CT对 ≤2cm肝癌子灶的诊 断的敏感性分析*

作者:王兴龙1 吴正阳2 孟令武3

所属单位:1.河南省商丘市第一人民医院影像 中心 (河南 商丘 476100) 2.郑州大学第一附属医院介入科 (河南 郑州 450000) 3.河南省商丘市第一人民医院介入 科 (河南 商丘 476100)

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摘要

目的 分析高速多排螺旋CT对 ≤2cm肝癌子灶的诊断敏感性。方法 回 顾性分析2013年4月-2016年10月我院64例 经组织病理学证实为原发性肝癌伴子灶 患者高速多排螺旋CT三期增强扫描数据, 分析其影像表现并与CT扫描后5d内数字减 影血管造影(DSA)结果进行对比分析,分 析高速多排螺旋CT对≤2cm肝癌子灶诊断 敏感性和影像学特征。结果 高速多排螺 旋CT共检测原发灶64个,子灶216个(左 叶49个,右叶167个),≤2cm子灶181个 (83.79%),<1cm子灶48个;DSA检测原发 灶64个,子灶总数161个(左叶42个,右叶 119个),其中≤2cm子灶119(73.91%),未 检出<1cm子灶;CT子灶大小分布、平均子 灶数目与DSA存在显著差异(P<0.05);CT 平扫下,低密度肝癌子灶184个,等密度 子灶22个;动脉期增强扫描显示轻度或明 显强化肝癌子灶184个;平衡期显示低密 度子灶211个,等密度子灶5个;有肝癌典 型特征子灶173个;三期增强扫描始终无 强化的低密度子灶37个;其中≤2cm子灶 强化率76.24%;161个肝癌子灶DSA染色均 明显,供血较好。结论 高速多排螺旋CT 对≤2cm肝癌子灶的诊断和检出较DSA有明 显优势,尤其适于更小癌灶(<1cm)诊断和 检出。

Objective To analyze the sensitivity of high-speed multi-slice spiral CT in diagnosis of satellite nodules ≤ 2cm of hepatocellular carcinoma (HCC). Methods A total of 64 patients with HCC satellite nodules confirmed by histopathological examination in our hospital from April 2013 - October 2016 were examined by high-speed multi-slice spiral CT three-phase contrast enhanced scanning. The results were compared with those of digital subtraction angiography (DSA) within 5 days after CT scanning. The sensitivity and imaging features of high-speed multi-slice spiral CT in diagnosis of HCC satellite nodules ≤ 2cm were analyzed. Results There were 64 primary lesions, 216 satellite nodules (49 satellite nodules in left lobe, 167 satellite nodules in right lobe), 181 satellite nodules (83.79%) ≤ 2cm and 48 satellite nodules <1cm detected by high-speed multislice spiral CT. There were 64 primary lesions, 161 satellite nodules (42 satellite nodules in left lobe, 119 satellite nodules in right lobe), 119 satellite nodules (83.79%) ≤ 2cm and none nodules <1cm detected by DSA. There were significant differences in the size distribution and the average number of satellite nodules between CT and DSA (P<0.05). CT plain scan showed 184 low-density HCC satellite nodules and 22 equal-density HCC satellite nodules. Contrast-enhanced scan showed 184 mild or obviously enhanced HCC satellite nodules in arterial phase, 211 low-density satellite nodules in balance phase, 5 equal-density satellite nodules. There were 173 typical HCC satellite nodules. Threephase contrast-enhanced scan showed 37 satellite nodules without enhancement. The enhancement rate of satellite nodules ≤ 2cm was 76.24%. DSA staining of 161 HCC satellite nodules was obvious, and the blood supply was good. Conclusion High-speed multi-slice spiral CT has obvious advantages over DSA in the diagnosis of HCC satellite nodules, especially suitable for diagnosis and detection of smaller tumors (<1cm).

【关键词】高速多排螺旋CT;肝癌子灶; DSA;敏感性

【中图分类号】R735.7;R814.42

【文献标识码】A

【DOI】10.3969/j.issn.1672- 5131.2017.12.021

前言

原发性肝癌死亡率高居恶性肿瘤第三位,严重威胁人类健康;原 发性癌灶数目、大小、位置、转移情况、癌栓情况等均影响肝癌患者 预后的重要因素,故临床提高肝癌子灶检出率,对患者意义重大[1]。 目前针对肝癌子灶检出的影像学方法较多,包括常规CT、数字减影血 管造影(DSA)等,DSA在小癌灶检出方面优于常规CT[2]。但近年随着CT 技术的迅猛发展,CT对≤2cm癌灶检测已有明显提高,高速多排螺旋CT 可经固体自扫描法形成层厚,能够同时得到4层1.25mm层厚图像,且图 像数据高达7.5幅/s,直接提升小癌灶检出率[3-4]。本研究针对我院64 例病理学证实为原发性肝癌的患者,对其≤2cm癌灶进行影像学诊断, 比较高速多排螺旋CT与DSA诊断敏感性和CT影像学特点。具体报道如 下。