目的 探讨肺内孤立性磨玻璃 密度结节(fGGO)良恶性病灶多层螺旋 CT(MSCT)的特点及其与病理学基础的关 系。方法 回顾性分析2015年1月-2016年 3月我院收治的75例fGGO患者的临床资 料，所有病例均经病理学证实。良性病 灶21例(炎症15例，不典型腺瘤样增生 (AAH)6例)；恶性病灶54例(细支气管肺泡 癌(BAC)37例，腺癌17例)。分析良恶性病 灶MSCT特点(位置、大小、形态、边缘、 病灶-肺界面、常见征象、磨玻璃密度结 节量化分型)。结果 恶性病灶患者年龄较 大、病灶也较大，与良性病灶比较差异 有统计学意义(P＜0.05)。恶性病灶形态 多呈圆形/类圆形，边缘多分叶征、毛刺 征、棘状突起；病灶-肺界面多清晰；常 见支气管充气征、血管集束征、胸膜凹 陷征，与良性病灶比较有统计学差异(P ＜0.05)。良性病灶多以Ⅰ型为主，恶性 病灶多以Ⅱ/Ⅲ型为主，比较有统计学差 异(P＜0.05)。结论 病灶MSCT特点与其 病理学基础有关，病灶大小、形态、边 缘、病灶-肺界面、分型，以及支气管充 气征、血管集束征、胸膜凹陷征等常见征 象，是鉴别诊断良恶性fGGO的重要依据。

Objective To investigate the MSCT features and pathologic foundation of pulmonary focal ground glass opacity (fGGO). Methods Clinical data of 75 fGGO patients treated in our hospital from January 2015 to March 2016 were analyzed retrospectively, including 21 cases benign lesions (15 cases pneumonia, 6 cases atypical adenomatous hyperplasia(AAH)) and 54 cases malignant lesions (37 cases bronchioloalveolar carcinoma (BAC), 17 cases adenocarcinoma). MSCT features of benign and malignant lesions were analyzed, including location, size, shape, border, interface, common signs, type). Results Compared with malignant lesions patients, the age and lesions size in benign lesions patients were small (P＜0.05). Malignant lesions shapes were mainly round or oval; the lesions edges were mainly lobular, spur, horn-like projection; the focal lung interfaces were clear; bronchial inflation sign, vascular bundle sign, pleural indentation sign were common in malignant lesions. There were significant differences between malignant and benign lesions (P<0.05). Most of benign lesions were type I, and malignant lesions were mainly type II / III, there were significant differences (P<0.05). Conclusion The characteristics of MSCT were related to pathologic basis. Lesion size, shape, edge, focal lung interface, typing, bronchial inflation sign, vascular bundle sign, pleural indentation sign, are important basis for the differential diagnosis of malignant and benign lesions.