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MRI动态增强联合 DWI征象对子宫内膜 癌肌层浸润和术前 分期的诊断研究

作者:黄社磊1 马 捷1 蒋华景2 詹雁辉1 王娟娟1

所属单位:1.深圳市人民医院放射科 2.深圳市人民医院超声科 (广东 深圳 518000)

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摘要

目的 探讨动态增强MRI(DCEMRI)联合弥散加权成像(DWI)对子宫内膜 癌诊断的准确性。方法 选择2014年1月至 2016年4月在本院治疗的子宫内膜癌确诊 病例82例,采用DCE-MRI联合DWI对子宫内 膜癌的肌层浸润情况及术前分期诊断,分 析其灵敏度与特异度,并判断其术前分期 与金标准的一致性。结果 DCE-MRI联合 DWI获得正确诊断肌层浸润深度70例,准 确率为95.89%;对浅肌层和深肌层浸润 的灵敏度、特异度、阳性预测值和阴性 预测值均高于90%。对75例病例的术前分 期获得正确的诊断,准确率为91.46%, 与金标准的一致性良好,Kappa指数为 0.88(P<0.05)。结论 DCE-MRI联合DWI成 像对子宫内膜癌的术前分期与肌层浸润深 度的诊断具有较高的准确度,能改善病人 的诊断和预后。

Objective To probe the diagnosing accuracy of DCE-MRI combined with DWI on endometrial carcinoma. Methods A total of 82 patients confirmed with endometrial carcinoma in this hospital from Jan 2014 to Apr 2016 were chosen. DCEMRI combined with DWI was adopted to diagnose the myometrial invasion and pathological stage of endometrial carcinoma. The sensitivity and specificity of diagnose were analyzed, and the consistency test between DCE-MRI combined with DWI and gold standard on pathological stage were conducted. Results The diagnosing accuracy of DCE-MRI combined with DWI on the myometrial invasion was 95.89% (70 cases), and the sensitivity, specificity, positive predictive value, and negative predictive value in shallow and deep myometrial invasion were all higher than 90%. The diagnosing accuracy on pathological stage was 91.46% (75 cases). There was strong consistency on diagnosing of pathological stage between DCE-MRI united to DWI and gold standard, with Kappa value being 0.88(P<0.05). Conclusion DCE-MRI combined with DWI has high diagnosing accuracy on myometrial invasion and preoperative pathological stage of endometrial carcinoma, and is expected to improve the diagnosing effect and prognosis of patients with endometrial carcinoma.

【关键词】磁共振成像;动态增强;子宫 内膜癌;肌层浸润;病理分期

【中图分类号】R445.2

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2017.10.033

前言

近年来,子宫内膜癌的发病率在全球范围呈上升趋势,已成为严 重威胁女性生命健康的生殖系统三大恶性肿瘤之一[1]。能否准确地判 断肌层浸润深度对子宫内膜癌的治疗意义重大[2],核磁共振成像动态 增强扫描(dynamic contrast-enhanced-MRI,DCE-MRI)能够明确肿瘤 的分期、位置和肌层浸润深度,大大提高了对子宫内膜癌肌层浸润深 度的敏感性和准确性的判断[3]。弥散加权成像(diffusion weighted imaging,DWI)是功能磁共振成像的重要组成部分,DWI序列上子宫内 膜癌弥散受限呈显著高信号,与周围正常肌层的低信号对比强烈,能 明确癌组织对肌层的浸润深度与癌症分期[4]。本研究采用DCE-MRI联合 DWI征象对子宫内膜癌的肌层浸润和术前分期进行诊断,旨在探讨其对 子宫内膜癌的诊断价值。