目的 探讨MR扩散张量成像在 胶质瘤分级中的研究价值。方法 31例 胶质瘤患者行3.0T MR常规及扩散张量 成像(DTI)检查，定量测量各向异性系 数FA及表观弥散系数值(ADC)，对低级 别、高级别胶质瘤组间定量参数的比较 采用Mann-Whitney U检验。以肿瘤ROI 中ADC与FA值作为临界点绘制出ROC曲 线，计算曲线下面积，确定诊断阈值， 评价其诊断效能。结果 14例低级别胶 质瘤的FA值为(139.4±81.3)；ADC值为 (1.36±0.21)×10-3mm2 /s；17例高级别 胶质瘤FA值为(103.1±41.5)，ADC值为 (1.09±0.28)×10-3mm2 /s.；2两组间参 数差异有统计学意义(P＜0.05)。以ADC 值作为临界点判断肿瘤低高级并绘制ROC 曲线，曲线下面积为0.79。以ADC值等于 1.11×10-3mm2 /s作为诊断阈值，区分低 高级肿瘤的敏感度为58.8%，特异度为 92.9%。以FA值作为临界点判断肿瘤低高 级 并绘制ROC曲线，曲线下面积为0.62。 以FA值等于178.9作为诊断阈值，区分低 高级肿瘤的敏感度为94.1%，特异度为 35.7%。结论 DTI中FA值及ADC值对胶质瘤 病理分级有重要的评估价值。

Objective To evaluate the value of diffusion tensor imaging（DTI）in cerebral glioma grading at 3.0T. Methods Thirty-one patients with pathologically confirmed cerebral glioma underwent DTI measurement. The values of FA of tumor tissues were measured and were correlated to the grade of cerebral gliomas by KruskalWallis H test. ROC analysis was used to assess the FA and ADC to distinguish between low-grade glioma (LGG) and high grade glioma (HGG). Results The FA values were (139.4±81.3) and (103.1±41.5) for LGG) and HGG, respectively. The ADC values were (1.36±0.21)×10-3mm2 /s and (1.09±0.28)×10-3mm2 /s for LGG and HGG, respectively. Statistical significance of FA and ADC values were found between LGG and HGG (P<0.05). Area under curve (AUC) of ADC/FA was 0.79/0.62, the sensitivity was 58.8%/94.1% and the specificity was 92.9%/35.7%, with a threshold value of 1.11×10- 3 (mm2 /s)/178.9. Conclusion The DTI parameter-FA and ADC have the potential clinical importance for cerebral glioma grading.