目的 探讨应用磁共振体素内不 相干运动弥散加权成像(IVIM-DWI)评价 脑白质疏松患者白质微循环灌注和水分 子扩散运动的价值。方法 常规MRI诊断 为脑白质疏松(LA)的患者20人，常规MRI 检查脑白质正常的对照组10人；对比LA 病灶区，LA病灶周围正常白质区和正常 对照组白质区的三个参数值，包括：f值 (灌注分数)；D值(真性扩散系数)；D* (假 性扩散系数)。结果 LA患者白质病灶区对 比病灶周围正常白质，f值和D值增高， 具有统计学意义，D* 值无明显差异。LA脑 白质病灶区对比正常对照组白质，f值增 高，但差异无明显统计学意义；D值增高 和D* 下降，差异具有统计学意义。脑白质 疏松病灶周围正常白质与正常对照组白 质对比，f值、D值、D* 值差异无统计学意 义。结论 磁共振体素内不相干运动弥散 加权成像能够定量评价脑白质疏松症的 微观结构变化和微循环灌注的变化。

Objective To investigate the application value of intravoxel incoherent motion diffusion weighted imaging(IVIM-DWI) in evaluating the microcirculation and water molecule diffusion of brain white matter of leukoaraiosis patients. Methods 20 cases of leukoaraiosis(LA) patients confirmed with conventional MR imaging, normal control group 10 cases. Compare LA white matter lesions, LA lesions surrounding normal white matter and normal control group white matter, including three parameters: f value (perfusion fraction), D value (true diffusion coefficient), D* (pseudo-diffusion coefficient). Results f value and D value is increased with statistical significance, when LA white matter lesions compared to LA surrounding normal white matter. There is no statistical significance in D* between the two groups. When LA white matter lesions compared to normal control group white matter, f value is increased, but without statistical significance. D value is increased and D* decreased with statistical significance. There is no statistical significance about f, D and D* value, when LA surrounding normal white matter compared to normal control group white matter. Conclusion Intravoxel incoherent motion diffusion weighted imaging can quantitatively evaluate the brain white matter microstructure changes and microcirculation perfusion.