目的 探讨利用ADC值预测鼻咽癌 治疗敏感性的价值。方法 142例鼻咽癌 在治疗前行MR扩散加权成像检查，获得 原发灶的ADC值。按照治疗后鼻咽癌原发 灶影像变化进行治疗敏感性分组，敏感 组104例、抗拒组38例。比较敏感性分组 与ADC值、T分期的关系。通过ROC曲线分 析ADC值预测敏感性的价值。结果 T1-T4 的ADC值分别为(0.818±0.111)×10- 3 m m2 /s、(0.756±0.169)×10- 3m m2 / s、(0.684±0.119)×10 - 3 m m 2 /s、 (0.667±0.093)×10-3mm2 /s，整体上存在 显著性差异(F=6.595，P=0.000)。敏感 组的ADC值(0.747±0.141)×10-3mm2 /s大 于抗拒组(0.658±0.129)×10-3mm2 /s， t=3.421、P=0.001。在敏感组内，T1-T4 的ADC值整体上不存在显著性差异。结论 ADC值和肿瘤乏氧、T分期密切相关，可成 为预测鼻咽癌治疗效果的有效手段。鼻咽 癌治疗敏感性有随着ADC值的升高而升高 的趋势。

Objective To investigate the value of ADC value in predicting the treatment sensitivity of nasopharyngeal carcinoma (NPC). Methods 142 cases of NPC were performed MR diffusion weighted imaging, and the ADC values of primary foci were obtained. According to the treatment results, these cases were divided to sensitive group (104 cases) and resistance group (38 cases). To analyze the relationship among groups, ADC values and T staging, estimate the value of ADC value in predicting the treatment sensitivity through the Az value of ROC curve. Results The ADC vales of T1 (0.818±0.111)×10-3mm2 /s, T2 (0.756±0.169)×10-3mm2 /s, T3 (0.684±0.119)×10- 3 mm2 /s and T4 (0.667±0.093)×10-3mm2 /s were significantly different on the whole (F=6.595, P=0.000). The ADC value of the sensitive group (747±0.141)10-3mm2 /s was greater than that in the resistance group (0.658±0.129)×10-3mm2 /s, (t=3.421, P=0.001). In sensitive group, T1 (0.822±0.114)×10-3mm2 /s, T2 (0.773±0.161)×10-3mm2 /s, T3 (0.697±0.114)×10-3mm2 /s and T4 (0.747±0.091)×10-3mm2 /s were significantly different on the whole (F=3.945, P=0.010). In resistance group, T1 and T4 were not significantly different on the whole. Conclusion ADC value is closely related to treatment sensitivity and T staging, which can be an effective method for predicting the treatment effect of nasopharyngeal carcinoma. The therapeutic sensitivity of NPC increased with the increase of ADC values.