目的 探讨PET/CT联合血清癌胚 抗原(CEA)、神经元特异性烯醇化酶(NSE) 和细胞角蛋白19片段21-1(CYFRA21-1)水 平在肺癌诊断中应用的价值。方法 选取 肺癌患者80例，肺良性病患者69例，另选 取同时期接受体检的健康人群40例，观察 PET/CT联合血清CEA、NSE和CYFRA21-1水 平在肺癌诊断中的准确性，并绘制受试者 工作曲线(ROC)，分析应用价值。结果 肺 癌组CEA、NSE和CYFRA21-1水平均显著高 于肺良性病组和健康组(P＜0.05)。PET/ CT+CEA+NSE+CYFRA21-1联合诊断肺癌敏感 性87.62%，特异性92.38%显著高于各指标 单独检测。结论 PET/CT与血清CEA、NSE 和CYFRA21-1联合对肺癌进行诊断，敏感 性和特异性明显高于各指标单独使用，在 肺癌诊断中有独特的临床价值。

Objective To discuss the application value of PET/CT combined with serum levels of cancer embryo antigen (CEA),neuron specific enzyme (NSE), and cytokeratin 19 fragment 21-1 (CYFRA21-1) in the diagnosis of lung cancer. Methods 80 cases of patients with lung cancer and 69 cases of patients with lung benign disease were selected,and another 40 cases of healthy people carried out physical examination during the same period were selected.The accuracy of PET/CT combined with CEA, NSE and CYFRA21-1 in the diagnosis of lung cancer was observed, and the receiver operating curve (ROC) was made to analyze the application value. Results The CEA, NSE and CYFRA21-1 levels in the lung cancer group were significantly higher than those in the lung benign disease group and the healthy group (P<0.05).The susceptibility of PET/ CT combined with CEA, NSE and CYFRA21-1 levels in the diagnosis of lung cancer was 87.62%, and the specificity was 92.38%,which were significantly higher than those by single detection method. Conclusion The susceptibility and specificity by the PET/ CT combined with CEA, NSE and CYFRA21-1 levels in the diagnosis of lung cancer are higher than those by single detection method,which has unique clinical value in the diagnosis of lung cancer.