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论著-头颈部

肺纤维化的CT和MRI诊断价值

作者:陈学武 李立峰 曹军林

所属单位:山东省莱芜市人民医院影像科(山东 莱芜 271100)

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摘要

目的探讨磁共振成像(MRI) 与高分辨率CT(HRCT)在肺纤维化诊断 中的价值。方法 以我院2013年6月-2014 年7月间经肺组织病理学活检证实为肺纤 维化患者30例为研究对象,分别对其进 行MRI扫描和高分辨率CT扫描,通过分析 影像特点探讨其在肺纤维化中的诊断价 值。结果 肺纤维化MRI检出率为56.67% (17/30),高分辨率CT检出率达到100% (30/30),二者比较差异有明显的统计 学意义(P<0.05);肺MRI以多参数和多 方位成像,对肺内部纤维化病变可以准 确定位,但纤维化肺组织MRI影像与正常 肺组织MRI均表现为低信号,分辨率不 如高分辨率CT影像,只能显示团块状纤 维化;高分辨率CT可以清晰显示胸膜下 线、小叶肺气肿、网状改变以及磨玻璃 样密度皮影等,高分辨率CT影响的分辨 率高于MRI影像。结论 MRI与CT在肺纤维 化诊断中各有优势,MRI更有利于指导外 科手术,而CT在临床诊断中具有更高的 价值,在临床上推荐采用高分辨率CT进 行诊断。

Objective To study the magnetic resonance imaging (MRI) and high resolution CT (HRCT) value in the diagnosis of pulmonary fibrosis. Methods 30 patients confirmed pulmonary fibrosis by pathology from June 2013 to July 2014 in my hospital were accepted MRI and high-resolution CT scans respectively, to compare their difference of diagnostic value by analyzing the image features. Results The pulmonary fibrosis detection rate of MRI was 56.67% (17/30), high resolution CT rate reached 100% (13/30), both of apparent significant differences (P<0.05); MRI parameters and multidimensional imaging of the lung, pulmonary fibrosis can accurately locate and fibrosis of lung tissue of MRI imaging and MRI of normal lung tissue is characterized by the low signal resolution than high resolution CT Imaging, can show massive fibrosis.High resolution CT can visualize the pleura referrals and interlobular emphysema, such as density, net change, and ground glass shadow, High resolution CT resolution higher than the effect of MRI images. Conclusions MRI and CT in the diagnosis of pulmonary fibrosis have advantages, MRI to guide the surgical procedure, and CT in the clinical diagnosis has a higher value, Recommends the use of high resolution CT in clinic diagnosis.

【关键词】病理活检;肺纤维化;MRI影像;CT影像;临床诊断

【中图分类号】R563.9;R445.2;R445.3

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2015.08.012

前言

当肺内成纤维细胞(fibroblast)受到伤害(化学性伤害或物理性伤 害)时,胶原蛋白、弹性素及蛋白醣类就会分泌胶原蛋白,对肺间组织 进行修补,使肺组织结构遭到破坏,进而发生内成纤维细胞和胶原结 缔组织增生,从而形成纤维化和蜂窝肺[1-2]。肺纤维化最常见的临床症 状为呼吸困难,因纤维化严重程度不同可分为:运动后呼吸困难;静 息性呼吸困难;进行性呼吸困难[3-4]。肺纤维化严重时使肺功能变差甚 至丧失,从而导致患者死亡,对人的健康以及生活质量和生命安全威 胁很大。有效的临床诊断才能为临床治疗提供合理的依据,因此特选 择30例肺纤维化患者为对象,通过分析其MRI和CT影像特点,探讨MRI 和CT在诊断该病中的价值。