简体中文

论著-头颈部

TIA患者颈内动脉虹吸部钙化与颈动脉分叉处狭窄的关系研究*

作者:刘碧英1 郑永豫1 陈光辉1 严金柱1 张国来1 曹代荣2 游瑞雄2 刘 颖2 佘德君2

所属单位:1.福建卫生职业技术学院附属省 级机关医院放射科 (福建 福州 350003) 2.福建医科大学附属第一医院放射 科 (福建 福州 350005)

PDF

摘要

目的探讨CT平扫检测短暂性脑 缺血发作(TIA)患者颈内动脉虹吸部钙化 与MSCTA显示颈动脉分叉处狭窄的关系。 方法 对84例同时行CT平扫及MSCTA检查 的TIA患者影像资料进行回顾性分析,根 据MSCTA图将颈动脉分叉处狭窄分为无狭 窄、轻度狭窄(0-49%)、中度狭窄(50- 69%)、重度狭窄(70-99%)、闭塞(100%) 五种;根据平扫CT图将颈内动脉虹吸部 钙化分为0-4级,0级为无钙化,1级为点 状钙化,2级为(弧形钙化占管壁的范围) <90°,3级90-270°,4级>270°,0-1 级为低级别钙化,2-4级为高级别钙化, 分析虹吸部钙化、钙化形态与颈动脉分 叉处狭窄的关系。结果 84例患者中,左 侧、右侧及混合组狭窄发生率为43%、43% 及58%;颈动脉虹吸部有钙化且钙化范围 越大高度提示颈动脉分叉处狭窄,诊断具 有较高的敏感性(73%)和特异性(71%);虹 吸部没有钙化的颈动脉较少发生中度或重 度的狭窄,即狭窄程度超过50%(诊断特异 度100%);虹吸部钙化无法有效预测颈动 脉中度和重度狭窄,诊断敏感性为5.8%。 结论 虹吸部钙化及钙化范围可以作为TIA 患者预测颈动脉分叉处狭窄的两项指标。

Objective To evaluate the relation between carotid siphon calcification with the presence of TIA on non-enhanced CT images and carotid artery bifurcation stenosis(CABS) on MSCTA images. Methods This IRB-waived retrospective study included 84 consecutive patients suspected of TIA who underwent non-enhanced CT and MSCTA of the head and neck. CABS was rated on CTA as not present or present with non-significant (0-40%), moderate (50-69%), significant (70-99%) and occlusion (100%). And carotid siphon calcification was classified into 5 grades on non-enhanced CT images including grade 0 (no calcification), grade 1 (small spotty foci of calcification), grade 2 (a single calcification occupying <90°), grade 3 (90-270°), grade 4 (>270°). Furthermore, grade 0-1 were defined as low grade calcification, and grade 2-4 were defined as high grade calcification. Presence, shape of carotid siphon calcification were analyzed the relationship with CABS. Results The presence of CABS were as follows: left side, 43%; right side, 43%; bilateral sides, 58%. The presence of carotid siphon calcification and bigger extent of calcification resulted in odds ratios for having CABS, with a high sensibility (73%) and specificity (71%). Absence of calcification in carotid artery siphon has a high negative predictive value for CABS in patients (specificity of diagnosis=100%). However, siphon calcification is not a reliable indicator of moderate and significant carotid artery stenosis (sensibility of diagnosis=5.8%). Conclusion Presence and extent of calcification in carotid artery siphon can be indicators of CABS in the patients with TIA.

【关键词】3D-MSCTA;虹吸部;钙化;颈动脉分叉处狭窄

【中图分类号】R445.3;R543

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2015.08.008

前言

对于短暂性脑缺血发作(transient ischemic stroke,TIA)的病 人,颈动脉分叉处狭窄被认为是很重要的危险因素。国内外研究[1-3]证 实动脉粥样硬化引起的颅内外动脉狭窄是TIA的主要病因,是缺血性脑 卒中重要的危险因素,大约有30%的脑梗死患者是由于颈动脉狭窄所 致。Marquering[4]等研究表明颈动脉分叉处钙化与颈动脉狭窄间没有 必然关系, 到目前为止国内外探讨颈动脉虹吸部钙化与颈动脉狭窄、 脑缺血性疾病的关系的报道较少。本研究的目的就是探讨颈内动脉虹 吸部钙化与颈动脉分叉处狭窄间的关系,评估脑缺血性疾病的危险程 度,并指导临床进行合理干预,为缺血性脑血管病的预防提供更全面 的方法。