Objective To explore the biochemical decoction combined with carboprost ammonia butyl alcohol three in treatment of uterine atony postpartum hemorrhage curative effect. Methods From December 2012 to December 2016 in our hospital for treatment of 27 patients as the research object, according to randomly divided into experimental group and control group. 14 cases in the experimental group, 13 cases in the control group,the control group were treated with carboprost ammonia butyl alcohol three treatment, patients in the experimental group using biochemical Decoction based on the control group, two groups were observed in patients with third labor time, 2 hours and 24 hours postpartum hemorrhage, and observe the adverse reactions of the two groups. Results The experimental group in the third labor time was significantly shorter than that of the control group [(6.35+1.19) min vs. (9.89+2.87) min], the amount of postpartum bleeding in 2 and 24 hours of experimental group were less than those of control group [(179.56+24.68) ml vs. (198.24+19.61) ml, (243.78+33.21) ml vs. (343.29+41.56) ml], the adverse effects rate of experimental group) was significantly lower than that of control group ((0% vs. 23.07%), all of the differences were statistically significant (P<0.05). Conclusion The postpartum hemorrhage caused by uterine inertia in patients with biochemical decoction combined with carboprost ammonia butyl alcohol three treatment, can significantly reduce the patient's bleeding after the operation, shorten labor time, reduce the incidence of postoperative complications, can be summarized in the clinical application.