Objective To observe the application values of optimized emergency nursing procedure in acute myocardial infarction, and analyze the influence of this nursing mode on prognosis. Methods 108 patients with acute myocardial infarction treated in our hospital were selected and randomly divided into the conventional group (n=54) and the optimized group (n=54). The conventional group was given routine emergency nursing, and the optimized group was given optimized emergency nursing. The prognosis, emergency rescue time, triage time, hospital stay, in-bed time and complications were compared in the two groups. Results The rescue success rate in the optimized group was higher than that in the conventional group (88.89% vs. 74.07%) (P<0.05). The triage time, emergency rescue time, hospital stay and in-bed time were less than those in the conventional group (P<0.05). The complication rate in the optimized group was lower than that in the conventional group (9.26% vs. 22.22%) (P<0.05). Conclusion Optimized emergency nursing procedure in the emergency department can not only shorten the rescue time, but also improve the success rate and prognosis of patients with acute myocardial infarction. Therefore it is worthy of clinical promotion.