Objective To investigate the effect of comprehensive expectoration adjunctive therapy on asthmatic bronchitis and its influence on airway hyperreactivity in children. Methods From May 2015 to Jan. 2017, 80 cases of children with asthmatic bronchitis in our hospital were selected as the research objects, and they were divided into observation group (n=40) and control group (n=40) according to their different treatment methods. The control group was given routine treatment and nursing, and the observation group was given additional comprehensive expectoration adjunctive therapy on the basis of the control group. The curative effects, inflammatory factors levels and pulmonary function changes before and after treatment, PC20FEV1 (FEV1 down 20% required the concentration of drug to be stimulated) in the two groups were compared. Results The total effective rate in the observation group was (92.5%) which was significantly higher than that in the control group (72.5%), after treatment, the levels of inflammatory factors in the observation group were significantly lower than those in the control group; the lung function indexes and the level of PC20FEV1 in the observation group after treatment were significantly higher than those in the control group, the difference was statistically significant (P<0.05). Conclusion Comprehensive expectoration adjuvant therapy can significantly not only reduce airway inflammation and airway hyperreactivity, but also improve lung function for children with asthmatic bronchitis. Thus, it is worthy of promotion.