Objective To study the efficacy of intravitreal injection of Conbercept on patients with diabetic retinopathy and its effects on visual function. Methods 110 DR patients (110 eyes) treated in our hospital were randomly divided into the observation group and the control group. The observation group (n=55, 55 eyes) was given intravitreal injection of Conbercept, and the control group (n=55, 55 eyes) was given intravitreal injection of triamcinolone acetonide. The efficacy of the two groups was compared. Results The best corrected visual acuity of the two groups were significantly improved after treatment (P<0.05), and the improvement in the observation group was higher than that in the control group (P<0.05). The level of serum vascular endothelial growth factor in the two groups was decreased significantly after treatment (P<0.05), and the decrease in the observation group was lower than that in the control group (P<0.05). The total adverse reaction rate in the control group was higher than that in the observation group (27.27% vs. 5.45%) (P<0.05). Conclusion Intravitreal injection of Conbercept can not only effectively improve patients’ visual performance, but also significantly reduce the VEGF level in patients with diabetic retinopathy, and it has high safety.