Objective To explore the comparison between cryodiagnosis and conventional paraffin diagnosis for thyroid diseases. Methods 1000 cases of thyroid disease treated by our hospital from October 2014 to October 2015 were selected as the study subjects. The pathological tissue of the patients after the operation was tested with the frozen section and conventional paraffin section,and the pathological results were compared. Results Of the 1000 patients, 672 were benign, accounting for 67.2%of the total cases. The 55 cases of hashimoto thyroiditis,accounting for 8.18% of the benign patients. Subacute thyroiditis in 5 cases, 0.74%of the patients with benign, 517 cases of nodular goiter,accounting for 76.93% of the patients with benign follicular adenoma,79 cases,11.76%of the patients with benign,GRVAES disease 6 cases, 0.89%of the patients with benign.328 cases of malignant tumor, which accounted for 32.8% of the total cases. 11 cases of medullary carcinoma and 33.54% of malignant patients. 7 cases of follicular cancer and 2.13% of malignant patients. There were 310 cases of papillary carcinoma,and 94.51 were malignant. Total compliance with 300, accounting for 91.46%. Basic compliance with 5 cases, accounting for 1.52%. Misdiagnosis of 20 cases,accounting for 6.1%. Delay in 3 cases, 0.91%. Conclusion The examination results of the frozen section can make accurate judgment of the patient's pathological condition, and it is a quick and easy way to check.Frozen sections of diagnosis of thyroid disease should summarize the clinical experience,constantly improve the materials and production technology, teacher should have many years experience in reading,in order to improve the diagnostic accuracy for the purpose, to reduce the misdiagnosis rate.