Objective To explore the application effects of problem-oriented health education on patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods 82 cases of patients with coronary heart disease who were treated in our hospital from March 2017 to March 2018 were enrolled in the study. According to the random number table method, the patients were divided into study group and control group, with 41 cases in each group. Control group was given routine nursing, and study group was given problem-oriented health education. Coagulation function [platelets (Plt), prothrombin time (PT), activated partial thromboplastin time (APTT)] and quality of life [quality of life assessment scale (SF)] were compared between the two groups before nursing and after 2 w of nursing. The adverse reactions of the two groups were recordedafter 2 wof nursing. Results Compared with before nursing, the quantity of Plt was decreased in the two groupsafter 2 w of nursing, and the quantity in study group was significantly lower than that in control group (P<0.05). The PT and APTT were obviously increased, and the two indexes in study group were significantly higher than those in control group (all P<0.05). The SF scores were significantly increased, and the score in study group was significantly higher than that in control group (all P<0.05). After 2 wof nursing, the total incidence rate of adverse reactions in study group was significantly lowerthan that in control group (all P<0.05). Conclusion Problem-oriented health education nursing for patients with coronary heart disease after PCI can reduce adverse reactions and improve quality of life.