Objective To investigate the effects of duloxetine combined with low-dose olanzapine on prognosis of patients with depression and suicidal tendency. Methods 83 patients with schizophrenia were randomly divided into observation group (41 cases) and control group (42 cases). The control group was treated with duloxetine. The observation group was treated with low-dose olanzapine on the basis of the control group. The course of treatment was 12 weeks. The Hamilton Depression Scale (HAMD) was performed to assess depression degree of patients. The self-rating idea of suicide scale (SSIOS) was performed to assess the occurrence of suicidal ideation. Results HAMD scores of the two groups at 8 and 12 weeks after treatment were decreased compared with those before treatment. And the decrease in the observation group was significant. The occurrence rates of suicidal ideation in the observation group at 8 weeks and 12 weeks after treatment were 60.98% and 41.46%, respectively. Which were significantly lower than those in the control group (80.95%, 64.29%). SSIOS scores of the two groups at 8 and 12 weeks after treatment were decreased compared with those before treatment. And the decrease in the observation group was significant (P<0.05). Conclusion Duloxetine combined with low-dose olanzapine is effective in improving depressive symptoms in patients with depression and suicidal tendency, and can significantly reduce the incidence of suicidal ideation.