Objective To explore the effect of nursing care for acute myocardial infarction in patients with acute myocardial infarction. Methods 68 patients with acute myocardial infarction treated in emergency internal medicine of our hospital from March 2015 to March-2017 were selected as the research objects, the patients were divided into control group (n=34 cases) and observation group (n=34 cases) according to random number table method, routine emergency nursing and emergency whole course optimization nursing were adopted respectively, compared two groups of nursing effects and rescue situations. Results The evaluation time, venous blood sampling time, ECG time, first aid time and hospitalization time of the observation group were significantly shorter than those of the control group(P<0.05). The satisfaction of the control group was 73.5%, the observation group was 94.1%, and the difference between the two groups was statistically significant (P<0.05). The recurrence rate of the observation group was 5.9%, and the intervention rate of intervention was 8.8%, the control group were 23.5% and 29.4% respectively, there was significant difference between the two groups (P<0.05). Conclusion In the emergency treatment of acute myocardial infarction, it can shorten the rescue time, improve the salvage effect, improve the prognosis and help to improve satisfaction, which is worthy of clinical application.