Objective To observe the efficacy of traditional Chinese medicine sitting bath combined with Titanoreine Suppository in the treatment of chronic perianal eczema. Methods 116 patients with chronic perianal eczema were divided into observation group and control group, with 58 cases in each group. Control group was given Titanoreine Suppository anal treatment after warm water sitting bath, and observation group was given traditional Chinese medicine sitting bath combined with Titanoreine Suppository, and they were treated for 1 month. The clinical efficacy indexes of the two groups were observed after the end of course. Results The total effective rate of treatment in observation group was higher than that in control group (89.66% vs 72.41%) (P<0.05). The scores of pruritus degree, lesion area and lesion morphology in the two groups were significantly decreased after treatment, and the scores in observation group were lower than those in control group (P<0.05). Conclusion Traditional Chinese medicine sitting bath combined with Titanoreine Suppository can significantly alleviate the pruritus degree of chronic perianal eczema, reduce the area of skin lesions, and improve the morphology of skin lesions, and it has remarkable efficacy.