Objective To observe the effects of intensive risk management in blue light irradiation for neonatal jaundice. Methods 490 children patients were divided into study group (intensive risk management + routine intervention, n=245) and control group (conventional intervention, n=245) according to the random number table method. The expression level of serum total bilirubin in the two groups was compared before intervention and after 5 d of intervention, and the occurrence of adverse events and nursing satisfaction were compared during intervention. Results After 5 d of intervention, the serum total bilirubin level was lower than that before intervention (all P<0.05), and the level in study group was lower than that in control group (all P<0.05). The incidence rate of adverse events was 4.08% in study group and was 13.88% in control group (χ2 =10.220, P=0.001). The nursing satisfaction of family members was 94.69% in study group and was 82.04% in control group (χ2 =5.390, P=0.020). Conclusion Intensive risk management can effectively reduce the risk of adverse events during blue light irradiation for children patients, and its effects are better than conventional nursing