Objective To summarize the experience in the treatment of differentiated thyroid carcinoma. Methods From September 2010 to March-2012, 30 patients with differentiated thyroid carcinoma were treated in our hospital. The open state of thyroid unilateral thyroidectomy and isthmus resection in 10 cases, ipsilateral thyroid lobe and leaf subtotal resection in 9 cases, thyroid gland near total resection or total thyroidectomy in 10 cases, 1 cases of thyroid function of palliative surgery, 15 cases of lymph node dissection of cervical lymph nodes, 1 cases of selective sweep of Qing Dynasty cervical lymph node dissection, 1 cases of classic. 131I radiotherapy combined with retinoic acid was performed 1 months after operation, and thyroid stimulating hormone therapy was performed at about 1 weeks after radiotherapy. Results There were 1 cases of adverse reactions after radiotherapy. 2 cases of temporary hypocalcemia, 1 years, 3 years, 5 years survival rate was 100.0%, ipsilateral thyroid lobe plus isthmic resection 5 cases of cervical lymph node metastasis, respectively the occurrence time of 10 months, 14 months, 20 months, 21 months and 27 months, no recurrence of metastasis. T3, T4, TSH, FT4, FT3 and preoperative difference was statistically significant (P<0.05), the indicators reached the control standard. The success rate of first nail cleaning was 76.7% (23/30). No permanent hypocalcemia, quality of life score is slightly lower than the normal level after operation than before operation (P <0.05). Conclusion The surgical treatment of cervical lymph node of 131I + + + + thyroxine retinoic acid cleaning is effective in the treatment of differentiated thyroid cancer, reduce postoperative metastasis, improve the survival rate after surgery; surgery and lymph node dissection according to gland size and location, TNM staging, combined with clinical manifestations to the thyroid gland.