Objective To observe the clinical efficacy of intravenous injection of salvianolate in the treatment of patients with acute cerebral infarction (ACI) and its effects on cerebral hemodynamics and oxidative stress indexes. Methods 108 patients with acute cerebral infarction admitted to our hospital were selected as subjects and were randomly divided into observation group and control group, with 54 cases in each group. Control group was given conventional treatment, and observation group was given intravenous injection of salvianolate on the basis of control group, and they were treated for 2 w. The cerebral hemodynamics [anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery (PCA)] and oxidative stress indexes [oxidized low density lipoprotein (OX-LDL), malondialdehyde (MDA)] were compared between the two groups after treatment. And the clinical efficacy [National Institute of Health Stroke Scale (NIHSS) reduction rate] was observed after the end of treatment. Results After treatment, the ACA, MCA and PCA in observation group were significantly lower than those in control group (P<0.05). The oxidative stress indexes OX-LDL and MDA were significantly lower than those in control group (P<0.05). After treatment, the total effective rate of NIHSS scale score in observation group was higher than that in control group (88.89% vs 64.82%). Conclusion Intravenous injection of salvianolate has significant clinical efficacy in the treatment of acute cerebral infarction, and it can effectively improve the cerebral hemodynamics and oxidative stress status.