Objective To explore the effects of different injection schemes of contrast media on the CT angiography (CTA) image quality of head and neck. Methods 96 cases of patients with head and neck CTA examinations from January 2014 and January 2017 in our hospital were selected and divided into the group A (n=48) and the group B (n=48) according to the random number table method. The contrast media of the two groups were 370mgI/mL iopamidol with the total amount of 60mL, and the patients were given the right anterior elbow vein injection with the injection rate of 5mL and then they were additionally given the normal saline with the total amount of 70mL. And the group A was given the saline injection rate of 5mL/s, and the group B was given the saline injection rate of 4mL/s. The objective image quality [average CT value, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR)], the subjective image quality [contrast degree of blood vessels and peripheral structures, lumen edge sharpness degree, noise and image definition], radiance dose [CT dose index (CTDI), CT dose length product (DLP), effective radiation dose (ED)] were compared between the two groups. Results There was no significant difference in the average CT value and SNR in the aortic arch and carotid bifurcation between the group A and the group B (P>0.05), and the CNR was significantly higher than that in the group B (P<0.05). The contrast degree of vessel and surrounding structures, the sharpness degree of lumen edge, noise and image definition in the group A were significantly higher than those in the group B (P<0.05), and there was no significant difference in the noise compared with that in the group B (P>0.05). There was no significant difference in the CTDI, DLP and ED between the group A and the group B (P>0.05). Conclusion Thefaster the additional saline injection rate is, the higher CTA image quality of head and neck is. And the same contrast media flow rate and the saline flushing rate can have good effects.