Objective To explore clinical value of enhanced CT scanning combined with detection of tumor markers in the diagnosis of renal carcinoma. Methods 60 patients with renal carcinoma confirmedbyclinical operation and pathology treated in our hospital from February 2014 to February 2015 were selected as the research objects, they underwent tumor markers examination, CT and enhanced CT scanning respectively, two examination methods were independently performed, examination results were analyzed independently. Pathological type, staging accuracy of different examination methods were compared, CT scan imaging performance of patients with renal carcinoma were analyzed. Results Accuracy rate of pathological stage in detection of tumor markers was higher than CT scan, accuracy rate of pathologic typing of CT scan was higher than detection of tumor markers. CT scan imaging performance were 21 cases of retroperitoneal lymph node metastasis, liver metastasis, enhanced scanning renal disorder showed significant enhanced change. 17 case of local contour of the lower pole of the kidney, abnormal density shadow could be seen, obvious lesions enhancement could be seen in percutaneous medullary junction after enhancement, parenchymal phase were equidensite. 12 cases of obvious increase of renal contour, low density range could be seen with sharpness of border, uneven density, no obvious enhancement in lesions after enhancement. 10 cases were complicated with liver, peritoneal metastasis, soft-tissue mass could be seen in kidney, obvious lesions enhancement could be seen after enhancement. Conclusion CT and enhanced CT scanning iconography have obvious characteristics, enhanced CT scanning, tumor markers examination have different advantages in pathologic typing and pathological stage in renal carcinoma, combined detection has important clinical value in diagnosis of renal carcinoma.