Objective To investigate the clinical value of CT three phase dynamic enhanced scan in the diagnosis of renal cell carcinoma. Methods Select 58 patients with renal cell carcinoma treated in our hospital from January 2015 to January 2017, collect the clinical data and imaging data of 58 patients, image analysis of plain scan and CT three phase enhanced scan in 58 patients with renal cell carcinoma (CT), the detection rate and diagnostic accuracy of CT plain scan and compare the CT three phase enhanced scan with the results of operation or pathological biopsy. Results 43 cases were diagnosed by CT plain scan, the accurate diagnosis rate was 74.13%, which was significantly lower than three phase dynamic enhanced scan 98.27% (57/58), the difference was statistically significant (χ2 =14.210, P<0.001). The mean CT value (32.17±8.54) HU and mean lesion diameter(4.95±4.30)cm in 58 patients with renal cell carcinoma were detected by CT scan. The density of most lesions was homogeneous, with the appearance of "burr" and "linear" structure in the perirenal space of the lesion. The three phase dynamic enhanced scan, the mean CT value (85.11±30.44) HU in the arterial phase, and the mean CT value (62.10±21.64) HU in the parenchymal phase, most of the lesions showed a round shape, and 6 patients showed irregular shape. The arterial phase showed varying degrees of height enhancement, of which 49 patients with enhanced visible boundary, the majority of patients with pseudocapsule, "short thorn" syndrome, central area of hemorrhage, necrosis and cystic change and calcification showed no obvious enhancement. Parenchymal enhancement degree gradually weakened, "fast" lesions showed features, venous phase scanning enhancement decreased significantly. Conclusion CT three phase dynamic enhanced scan is of high accuracy in diagnosis of renal cell carcinoma, and can clearly display the lesion, providing reliable imaging data for clinical treatment.