Objective To study the clinical application of 64-slice CTA in the diagnosis of intracranial aneurysms. Methods The 64-slice CTA imaging data of 49 patients with spontaneous subarachnoid hemorrhage in our hospital were analyzed retrospectively. The imaging data were analyzed by volume rendering and maximum intensity projection, and the sensitivity, specificity, accuracy, positive predictive value, negative predictive value and consistency of 64 -slice CTA were calculated with digital subtraction angiography as the golden standard. Results In 49 patients with SAH, 52 IA in 45 cases were detected by DSA, and parent arteries included 5 anterior cerebral artery (ACA), 7 middle cerebral artery (MCA), 2 posterior cerebral artery (PCA), 16 anterior communicating artery (AComA), 3 posterior communicating artery (PComA), 17 internal carotid artery C1 segments (ICA) and 2 vertebral artery (VA). A total of 55IA in 46 patients were detected by 64 -slice CTA, and parent arteries included 5 ACA, 6 MCA, 16 AComA, 6 PComA, 17 ICA and 5 VA. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value and consistency (kappa) of 64 -slice CTA in the diagnosis of IA were 100.00%, 75.00%, 93.87%, 97.72%, 60.00% and 0.846 respectively, suggesting good consistency. Couclusion 64-slice CTA in IA is not only cheap and safe but also can clearly reflect the shape, location and the adjacent relationship with the surrounding structure of IA.