Objective To discuss the diagnosis of otosclerosis, a high-resolution CT (HRCT) BMD measurement of use value. Methods April 2011 to March 2012 in our hospital patients with otosclerosis (experimental group) 40 cases of normal controls (control group) 42 cases, the window area is set in the vestibular bone density CT value ROI The the measure, while patients with otosclerosis air-bone gap measure hearing and speech frequency air conduction. The two samples of normal ear and ear bone sclerosis average CT value recording, the t-test results for otosclerosis patient hearing level and CT value Pearson correlation coefficient analysis, CT diagnosis of otosclerosis efficacy using ROC curve analysis. Results CT Pretrial area between the control group 1797.72-2675.78HU, average (2168±22.64) HU, the experimental group Pretrial district CT values between 457.82-2273.34HU, average (1368.23±75.43) HU, the two The mean CT values were compared, the control group was significantly higher than those in the experimental group (P<0.01); the experimental group, the average CT value of air-bone gap (r=- 0.01, P=0.93), and the speech frequency air conduction threshold (r=0.17, P=0.18) were not significantly different between. CT diagnosis using an average value of the sensitivity of 82.2%, ROC curve otosclerosis to identify an area of 0.85 (P<0.05), the diagnostic threshold 1927.16HU, specificity was 91.3%. Conclusion The diagnosis of otosclerosis, the bone density measurement effect is obvious, but on hearing assessment is not ideal.