Objective To study the value of chest CT perfusion imaging(CTP) in the evaluation of histological type, staging and tumor necrosis of peripheral lung cancer. Methods 52 cases of patients with peripheral lung cancer confirmed by pathology in our hospital were selected as the research objects. The size, shape, density, etc. were observed by CT. CT perfusion parameters were calculated, including perfusion value(PER), enhanced peak value (PE), blood volume (BV) and time to peak (TTP) of contrast agents. The differences in CT perfusion values in patients of different histological types, staging and tumor necrosis were analyzed. Results For clinical staging, compared with T1 and T2, PER, PE and BV were significantly higher (P<0.05) and TTP was significantly lower (P<0.05). Compared T2with T3, PER, PE and BV were significantly lower (P<0.05). The difference in TTP between T2 and T3was not statistically significant (P>0.05); In terms of histological types, PER, PE and BV of small cell carcinoma [(64.52±34.36), (60.20±31.74), (34.12±16.36)] were higher (P>0.05) and adenocarcinoma was higher than squamous carcinoma but the comparison was not statistically significant (P>0.05); In terms of tumor necrosis, PER, PE and BV in the mom-necrosis group were significantly higher than those in necrosis group (P<0.05) while TTP was significantly lower than that in the necrosis group (P<0.05). Conclusion Chest CT perfusion scan is of certain value in diagnosis of the staging, histological types and tumor necrosis of patients with peripheral lung cancer, especially for the diagnosis of tumor necrosis of peripheral lung cancer which can be clearly shown. It can provide important clinical basis for the early diagnosis, preoperative staging and evaluation of prognosis of peripheral lung cancer.