Objective To investigate the application value of treadmill exercise test (TET), dynamic electrocardiogram (DCG) and coronary CT angiography (CTA) in the diagnosis of coronary heart disease (CHD). Methods A total of 150 patients with suspected CHD who were admitted to the hospital during the period from May 2017 to May 2018 were enrolled in the study. All patients underwent TET, DCG and CTA. With coronary angiography (CAG) as the golden standard, the diagnostic efficiency of TET, DCG and CTA were compared. Results The sensitivity, specificity and accuracy of CTA in the diagnosis of CHD (82.11%, 81.82% and 82.00%) were higher than those of TET (72.63%, 72.73% and 72.67%) and DCG (63.16%, 58.18% and 61.33%). The detection rates of the number of coronary artery lesions and the degree of coronary artery stenosis in patients with CHD by CTA were higher than those by TET or DCG significantly (P<0.05). The detection rates of the number of coronary artery lesions and the degree of coronary artery stenosis by TET were slightly higher than those by DCG (P>0.05). Conclusion The sensitivity, specificity and accuracy of CTA are higher than those of TET and DCG in the diagnosis of CHD. The detection rates of the number of coronary artery lesions and the degree of coronary artery stenosis in CHD by CTA are significantly higher than those by TET or DCG.