Objective To evaluate the value of PHILPS Brilliance iCT in restenosis of coronary artery stent and its application in follow-up. Methods A retrospective analysis of 89 patients (112 stents) after percutaneous coronary intervention (percutaneous coronar intervention, PCI) underwent coronary artery CT angiography (coronary computed tomographic angiography, CCTA) and coronal coronary artery angiography (coronary computed tomographic angiography, CCTA), respectively. The coronary angiography (CAG) examination was used to collect the diagnostic data of CCTA and CAG. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of the stent restenosis after the CCTA diagnosis of PCI were calculated with the results of CAG diagnosis as the reference standard. Results 4 stents in 112 stents were not evaluated because of artifacts in the lumen, and the remaining 108 stents could be evaluated. CCTA showed 92 stent patency and 16 stent restenosis. CAG showed 90 stent restenosis and 18 stent restenosis. The sensitivity of CCTA diagnostic stent restenosis was 88.9% (16/18), the specificity was 100% (90/90), the positive predictive value was 100% (16/16), negative predictive value was 97.8% (90/92), and the diagnostic accuracy was 98.1% (106/108). Conclusion PHILPS Brilliance iCT coronary artery angiography can clearly display the status of the stent and accurately evaluate the degree of stent restenosis. It is a noninvasive method to evaluate the stent restenosis after PCI. It is of great clinical value for the follow-up of patients after PCI, and can be used as the current clinical practice. Noninvasive examination is the first choice for assessing coronary stent restenosis.