Objective To compare the value of CT perfusion imaging (CTPI) versus superb microvascular imaging (SMI) in evaluating the blood supply of active lesions after interventional operation for liver cancer. Methods Forty-eight patients undergoing interventional operation for liver cancer were selected. They were examined with CTPI and SMI at 6 weeks after operation. With digital subtraction angiography (DSA) as the golden standard, the accuracy was compared between CTPI and SMI in evaluating blood supply of active lesions after interventional operation for liver cancer. Results DSA showed that of the 52 lesions, there were 46 lesions with blood supply and 6 lesions without. The sensitivity, specificity, accuracy and Kappa value of CTPI for blood supply of active lesions after operation were 95.65% (44/46), 100.00% (6/6), 86.15% (50/52) and 0.84, respectively, while those of SMRI were 82.61% (38/46), 83.33% (5/6), 82.69% (43/52) and 0.44, respectively. The accuracy and sensitivity of CTPI were significantly higher than those of SMI (P<0.05). Conclusion Results of the two examination methods are consistent with those of DSA. Compared with SMI, the accuracy of spiral CTPI is relatively higher in assessing the blood supply of active lesions after interventional operation for liver cancer, and it can provide effective guidance for evaluation of the prognosis of patients.