Objective To investigate the value of diffusion weighted imaging (DWI) and its MRI enhanced scan in evaluating the early curative effect of transcatheter arterial chemoembolization (TACE) interventional therapy on liver cancer. Methods A total of 210 patients with liver cancer treated by TACE interventional therapy in the hospital from June 2015 to August 2016 were enrolled in the study, and they were examined with DWI scan and MRI enhanced scan before operation and after operation respectively. Referring to the Response Evaluation Criteria In Solid Tumors (RECIST), the treatment outcomes were divided into effective group and ineffective group. Imaging findings of patients were observed before and after treatment, and imaging quantitative changes were compared between the two groups before and after treatment. Results In the 210 patients, a total of 260 lesions were detected, and the average diameter of tumors was about 7.56cm. The imaging features of patients with liver cancer were typical before and after TACE. The ADC values of lesions in patients with liver cancer after operation were significantly higher than those before operation. The values of CER arterial phase and SIR arterial phase in patients with liver cancer after operation were significantly lower than those before operation (P<0.05). After operation, the ADC value of effective group was significantly larger than that of the ineffective group, but the CER arterial phase and SIR arterial phase were significantly smaller than those in the ineffective group (P<0.05). Conclusion DWI and its MRI enhanced scan can effectively assess the survival and necrosis of lesions in patients with liver cancer after TACE interventional therapy, which is of important reference value in evaluating the early curative effect and guiding the further treatment.