Objective To investigate the application value of computer tomographic angiography (CTA) combined with adaptive statistical iterative reconstruction (ASIR) in patients with coronary artery disease. Methods The clinical data of 78 patients with coronary artery disease treated in our hospital from February 2012 to April 2016 were collected. All patients were examined with CTA or CTA combined with ASIR imaging. Among them, 38 patients were examined with CTA (A group), and the scanning data were reconstructed with 120 kVP combined with filtered back projection (FBP). The other 40 patients were examined with CTA combined with ASIR and the data were reconstructed with ASIR 40% (B group). The imaging quality and effective radiation dose of the two groups were compared. Results The proportion of image quality score of 1 point in B group was higher than that in A group, and the proportion of 2 points was lower than that in A group (P<0.05). The signal-to-noise ratio (SNR) and the contrast to noise ratio (CNR) in B group were higher than those in A group, and the noise was lower than that in A group (P<0.05). The CT dose index volume (CTDIvol), dose length product (DLP) and effective dose (ED) in B group were lower than those in A group (P<0.05). Conclusion CTA combined with ASIR can improve the imaging quality of patients with coronary artery disease and reduce the radiation dose of patients, which is safe and feasible.